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. 2001 Dec;15(6):1051-61.
doi: 10.1016/s1074-7613(01)00252-7.

CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation

M A Daniels  1 , L Devine, J D Miller, J M Moser, A E Lukacher, J D Altman, P Kavathas, K A Hogquist, S C Jameson
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Free article

CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation

M A Daniels et al. Immunity. 2001 Dec.
Free article

Abstract

CD8 serves both as an adhesion molecule for class I MHC molecules and as a coreceptor with the TCR for T cell activation. Here we study the developmental regulation of CD8-mediated binding to noncognate peptide/MHC ligands (i.e., those not bound by the TCR). We show that CD8's ability to bind soluble class I MHC tetramers and to mediate T cell adhesion under shear flow conditions diminishes as double-positive thymocytes mature into CD8(+) T cells. Furthermore, we provide evidence that this decreased CD8 binding results from increased T cell sialylation upon T cell maturation. These data suggest that CD8's ability to interact with class I MHC is not fixed and is developmentally regulated through the T cell's glycosylation state.

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