Review
doi: 10.1016/s1360-1385(01)02151-3.
Organellar peptide deformylases: universality of the N-terminal methionine cleavage mechanism
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- PMID: 11738381
- DOI: 10.1016/s1360-1385(01)02151-3
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Review
Organellar peptide deformylases: universality of the N-terminal methionine cleavage mechanism
Trends Plant Sci.
2001 Dec.
Abstract
Most mature proteins do not retain their initial N-terminal amino acid (methionine in the cytosol and N-formyl methionine in the organelles). Recent studies have shown that dedicated machinery is involved in this process in plants. In addition to cytosolic and organelle-targeted methionine aminopeptidases, organellar peptide deformylases have been identified. Here, we attempt to answer questions about the mechanism, specificity and significance of N-terminal methionine cleavage in plant organelles. It seems to be universal because orthologues of plant deformylases are found in most living organisms.
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