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Review

. 2001 Nov 20;98(24):13476-8.

doi: 10.1073/pnas.251530798.

Glucose and cAMP: adversaries in the regulation of hepatic gene expression

H C Towle¹

Affiliations

PMID: 11717416
PMCID: PMC61063
DOI: 10.1073/pnas.251530798

Review

Glucose and cAMP: adversaries in the regulation of hepatic gene expression

H C Towle. Proc Natl Acad Sci U S A. 2001.

. 2001 Nov 20;98(24):13476-8.

doi: 10.1073/pnas.251530798.

Author

H C Towle¹

Affiliation

¹ Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. towle@mail.ahc.umn.edu

PMID: 11717416
PMCID: PMC61063
DOI: 10.1073/pnas.251530798

No abstract available

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Figures

Figure 1
Schematic of the roles of ChREBP and SREBP in regulation of lipogenic enzyme gene transcription. Most lipogenic enzyme genes (e.g., fatty acid synthase) have response elements for binding ChREBP (ChoRE) and SREBP (SRE). These two factors work synergistically to induce transcription of the lipogenic enzyme genes in the presence of glucose and insulin. Glucagon, through its intracellular mediator cAMP, and polyunsaturated fatty acids (PUFAs) act to inhibit the activity of ChREBP and SREBP, respectively. In this manner, the output of lipogenic enzyme gene production is integrated to multiple nutrient and hormonal signals.

See this image and copyright information in PMC

Comment on

Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein.
Kawaguchi T, Takenoshita M, Kabashima T, Uyeda K. Kawaguchi T, et al. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13710-5. doi: 10.1073/pnas.231370798. Epub 2001 Nov 6. Proc Natl Acad Sci U S A. 2001. PMID: 11698644 Free PMC article.

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