Review
doi: 10.1083/jcb.200108110.
Epub 2001 Oct 15.
The concept of self-organization in cellular architecture
Affiliations
- PMID: 11604416
- PMCID: PMC2198832
- DOI: 10.1083/jcb.200108110
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Review
The concept of self-organization in cellular architecture
J Cell Biol.
.
Abstract
In vivo microscopy has recently revealed the dynamic nature of many cellular organelles. The dynamic properties of several cellular structures are consistent with a role for self-organization in their formation, maintenance, and function; therefore, self-organization might be a general principle in cellular organization.
Figures
Self-assembly versus self-organization. In self-assembly, a set of components assembles into a stable, static structure that reaches a thermodynamic equilibrium. In self-organization, a set of components assembles into a steady-state, dynamic structure.
Dynamic components generate stable structures. (A) Tubulin subunits are continuously exchanged from microtubule filaments. (B) Pre-mRNA splicing factors continuously cycle between the SFC and the nucleoplasm. (C) Membrane continuously flows throughout the Golgi complex.
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