Review
doi: 10.1002/biof.5520140103.
RNA binding proteins and selenocysteine
Affiliations
- PMID: 11568435
- DOI: 10.1002/biof.5520140103
Item in Clipboard
Review
RNA binding proteins and selenocysteine
Biofactors.
2001.
Abstract
Selenocysteine is incorporated into protein by a complex co-translational mechanism that involves both cis and trans acting factors. Among the trans-acting factors are RNA binding proteins that interact with the selenoprotein 3' UTRs at a sequence known as the selenocysteine insertion sequence (SECIS). These factors are generally referred to as SBPs, and in this review we will discuss the history of the SBPs, and give a detailed description of the recently identified SBP2 which is the only SBP known to be required for Sec insertion. The mechanism by which SBP2 may be involved in this process will be discussed.
Similar articles
-
Characterization of the UGA-recoding and SECIS-binding activities of SECIS-binding protein 2.RNA Biol. 2014;11(11):1402-13. doi: 10.1080/15476286.2014.996472. RNA Biol. 2014. PMID: 25692238 Free PMC article.
-
Characterization of the SECIS binding protein 2 complex required for the co-translational insertion of selenocysteine in mammals.Nucleic Acids Res. 2005 Sep 9;33(16):5172-80. doi: 10.1093/nar/gki826. Print 2005. Nucleic Acids Res. 2005. PMID: 16155186 Free PMC article.
-
Selenocysteine incorporation directed from the 3'UTR: characterization of eukaryotic EFsec and mechanistic implications.Biofactors. 2001;14(1-4):17-24. doi: 10.1002/biof.5520140104. Biofactors. 2001. PMID: 11568436 Review.
-
Functional analysis of the interplay between translation termination, selenocysteine codon context, and selenocysteine insertion sequence-binding protein 2.J Biol Chem. 2007 Dec 21;282(51):36797-807. doi: 10.1074/jbc.M707061200. Epub 2007 Oct 22. J Biol Chem. 2007. PMID: 17954931 Free PMC article.
-
[Methods to Biosynthesize Mammalian Selenocysteine-Containing Proteins in vitro].Mol Biol (Mosk). 2016 Jan-Feb;50(1):44-50. doi: 10.7868/S0026898416010213. Mol Biol (Mosk). 2016. PMID: 27028810 Review. Russian.
Cited by
-
Regulation of gene expression by stop codon recoding: selenocysteine.Gene. 2003 Jul 17;312:17-25. doi: 10.1016/s0378-1119(03)00588-2. Gene. 2003. PMID: 12909337 Free PMC article. Review.
-
Selenium-Dependent Antioxidant Enzymes: Actions and Properties of Selenoproteins.Antioxidants (Basel). 2018 May 14;7(5):66. doi: 10.3390/antiox7050066. Antioxidants (Basel). 2018. PMID: 29758013 Free PMC article. Review.
-
Comparative genomic analysis of selenium utilization traits in different marine environments.J Microbiol. 2020 Feb;58(2):113-122. doi: 10.1007/s12275-020-9250-0. Epub 2020 Jan 29. J Microbiol. 2020. PMID: 31993987
-
Tolerance to Selenoprotein Loss Differs between Human and Mouse.Mol Biol Evol. 2020 Feb 1;37(2):341-354. doi: 10.1093/molbev/msz218. Mol Biol Evol. 2020. PMID: 31560400 Free PMC article.
-
Selenium Discrepancies in Fetal Bovine Serum: Impact on Cellular Selenoprotein Expression.Int J Mol Sci. 2024 Jul 1;25(13):7261. doi: 10.3390/ijms25137261. Int J Mol Sci. 2024. PMID: 39000368 Free PMC article.
