[Anti-angiogenesis - a therapy concept in the treatment of head and neck carcinomas? A review]
- PMID: 11555787
- DOI: 10.1055/s-2001-17090
[Anti-angiogenesis - a therapy concept in the treatment of head and neck carcinomas? A review]
Abstract
Background: Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy that is now the sixth most common neoplasm in the world. Despite numerous advances in treatment, the long-term survival has remained the same for the last 25 years. Angiogenesis has been shown to be important for HNSCC tumour growth and metastasis. Therefore, inhibitors of angiogenesis are a new class of anti-neoplastic substances that might be a powerful complement to conventional therapy in HNSCC.
Material and methods: The role of angiogenesis in HNSCC as well as preclinical and clinical trials concerning inhibitors of tumor-angiogenesis are discussed here.
Results: Many of the investigated angiogenesis inhibitors demonstrated anti-tumor effects in preclinical and clinical trials. In a few cases, partial remission was observed.
Conclusions: Anti-angiogenic therapy will undoubtly have the potential to change standard tumor therapies. Some anti-angiogenic substances appear to be promising candidates for a clinical use in the therapy of HNSCC.
Similar articles
-
[The clinical perspective of angiogenesis inhibitors].Ned Tijdschr Geneeskd. 2003 Aug 30;147(35):1675-80. Ned Tijdschr Geneeskd. 2003. PMID: 14513538 Review. Dutch.
-
The platelet-derived growth factor receptor as a target for vascular endothelial growth factor-mediated anti-angiogenetic therapy in head and neck cancer.Int J Oncol. 2009 Jan;34(1):255-61. Int J Oncol. 2009. PMID: 19082496
-
Epidermal growth factor receptor biology in head and neck cancer.J Clin Oncol. 2006 Jun 10;24(17):2666-72. doi: 10.1200/JCO.2005.04.8306. J Clin Oncol. 2006. PMID: 16763281 Review.
-
[Antivascular strategies--a new concept for diagnosis and therapy of head and neck cancer. A review].Laryngorhinootologie. 2002 Jul;81(7):509-15. doi: 10.1055/s-2002-33284. Laryngorhinootologie. 2002. PMID: 12173062 Review. German.
-
Targeting angiogenesis in head and neck cancer.Semin Oncol. 2008 Jun;35(3):274-85. doi: 10.1053/j.seminoncol.2008.03.005. Semin Oncol. 2008. PMID: 18544442 Review.
Cited by
-
[Plastic surgery of skin defects in the face. Principles and perspectives].HNO. 2005 Dec;53(12):1020-36. doi: 10.1007/s00106-005-1335-x. HNO. 2005. PMID: 16220282 Review. German.
-
[Regenerative medicine in head and neck reconstructive surgery].HNO. 2008 Mar;56(3):262-74. doi: 10.1007/s00106-007-1604-y. HNO. 2008. PMID: 18034220 Review. German.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
