doi: 10.1126/science.1061662.
Recombination in the hemagglutinin gene of the 1918 "Spanish flu"
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- PMID: 11546876
- DOI: 10.1126/science.1061662
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Recombination in the hemagglutinin gene of the 1918 "Spanish flu"
Science.
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Abstract
When gene sequences from the influenza virus that caused the 1918 pandemic were first compared with those of related viruses, they yielded few clues about its origins and virulence. Our reanalysis indicates that the hemagglutinin gene, a key virulence determinant, originated by recombination. The "globular domain" of the 1918 hemagglutinin protein was encoded by a part of a gene derived from a swine-lineage influenza, whereas the "stalk" was encoded by parts derived from a human-lineage influenza. Phylogenetic analyses showed that this recombination, which probably changed the virulence of the virus, occurred at the start of, or immediately before, the pandemic and thus may have triggered it.
Comment in
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Virology. A molecular whodunit.Science. 2001 Sep 7;293(5536):1773-5. doi: 10.1126/science.1065206. Science. 2001. PMID: 11546856 No abstract available.
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Virology. The origin and control of pandemic influenza.Science. 2001 Sep 7;293(5536):1776-7. doi: 10.1126/science.1063817. Science. 2001. PMID: 11546857 No abstract available.
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Questioning the evidence for genetic recombination in the 1918 "Spanish flu" virus.Science. 2002 Apr 12;296(5566):211 discussion 211. doi: 10.1126/science.296.5566.211a. Science. 2002. PMID: 11951002 No abstract available.
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