Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2001 Aug;24(8 Suppl):III13-7.
doi: 10.1002/clc.4960241504.

Newer risk markers and surrogate endpoints in atherosclerosis management

C M Ballantyne  1
Affiliations
Review

Newer risk markers and surrogate endpoints in atherosclerosis management

C M Ballantyne. Clin Cardiol. 2001 Aug.

Abstract

Risk markers that allow improved and individualized assessment of atherosclerotic disease risk and response to treatment are needed. Current candidate markers include cell adhesion molecules, such as intercellular adhesion molecule-1 and E-selectin, and inflammatory markers, such as C-reactive protein; advances in genomics and proteomics will suggest additional candidate markers. Noninvasive imaging procedures such as electron-beam computed tomography and magnetic resonance imaging also show considerable promise for monitoring disease status and response to treatment, and ultimately could provide surrogate endpoints for clinical trials of therapeutic interventions.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Springer TA : Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol 1995; 57: 827–872 - PubMed
    1. O'Brien KD, Allen MD, McDonald TO, Chait A., Harlan JM, Fishbein D., McCarty J., Ferguson M, Hudkins K., Benjamin CD, Lobb R., Alpers CE, Vascular cell adhesion molecule‐1 is expressed in human coronary atherosclerotic plaques. J Clin Invest 1993; 92: 945–951 - PMC - PubMed
    1. Hwang S‐J, Ballantyne CM, Sharrett AR, Smith LC, Davis CE, Gotto AM Jr. Boerwinkle E., Circulating adhesion molecules VCAM‐1, ICAM‐1, and E‐selectin in carotid atherosclerosis and incident coronary heart disease cases: The Atherosclerosis Risk in Communities (ARIC) study. Circulation 1997; 96: 4219–4225 - PubMed
    1. Ridker PM, Hennekens CH, Roitman‐Johnson B., Stampfer MJ, Allen J., Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men. Lancet 1998; 351: 88–92 - PubMed
    1. Abe Y., El‐Masri B., Kimball KT, Pownall H., Reilly CF, Osmundsen K., Smith CW, Ballantyne CM, Soluble cell adhesion molecules in hypertriglyceridemia and potential significance on monocyte adhesion. Arterioscler Thromb Vase Biol 1998; 18: 723–731 - PubMed

MeSH terms