Translating the histone code
- PMID: 11498575
- DOI: 10.1126/science.1063127
Translating the histone code
Abstract
Chromatin, the physiological template of all eukaryotic genetic information, is subject to a diverse array of posttranslational modifications that largely impinge on histone amino termini, thereby regulating access to the underlying DNA. Distinct histone amino-terminal modifications can generate synergistic or antagonistic interaction affinities for chromatin-associated proteins, which in turn dictate dynamic transitions between transcriptionally active or transcriptionally silent chromatin states. The combinatorial nature of histone amino-terminal modifications thus reveals a "histone code" that considerably extends the information potential of the genetic code. We propose that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Comment in
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Exception to eukaryotic rules.Science. 2001 Dec 21;294(5551):2477. doi: 10.1126/science.294.5551.2477b. Science. 2001. PMID: 11770515 No abstract available.
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