Review
doi: 10.1038/35086062.
Pathophysiology of levodopa-induced dyskinesia: potential for new therapies
Affiliations
- PMID: 11484001
- DOI: 10.1038/35086062
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Review
Pathophysiology of levodopa-induced dyskinesia: potential for new therapies
Nat Rev Neurosci.
2001 Aug.
Abstract
Involuntary movements--or dyskinesias--are a debilitating complication of levodopa therapy for Parkinson's disease, and is experienced in most patients. Despite the importance of this problem, little was known about the cause of dyskinesia until recently; however, this situation has changed significantly in the past few years. Our increased understanding of levodopa-induced dyskinesia is not only valuable for improving patient care, but also in providing us with new insights into the functional organization of the basal ganglia and motor systems.
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