doi: 10.1074/jbc.C100357200.
Epub 2001 Aug 1.
Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch
Affiliations
- PMID: 11483588
- DOI: 10.1074/jbc.C100357200
Item in Clipboard
Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch
J Biol Chem.
.
Free article
Abstract
The intramembrane cleavage of beta-amyloid precursor protein by gamma-secretase is the final step in the generation of amyloid beta-protein. A 59- or 57-residue C-terminal fragment called CTFgamma is produced concomitantly. Putative CTFgamma generated in rat brain membrane preparations was purified and sequenced. Instead of CTFgamma, shorter 50- and 49-residue fragments were identified. In addition, we found similar C-terminal fragments of beta-amyloid precursor-like proteins 1 and 2; these were also cleaved at corresponding sites. This newly identified cleavage occurs at a site two to five residues inside the cytoplasmic membrane boundary, which is very similar to gamma-secretase-like cleavage of Notch 1.
Similar articles
-
Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).Biochemistry. 2003 Jan 14;42(1):137-44. doi: 10.1021/bi026888g. Biochemistry. 2003. PMID: 12515548
-
Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch.EMBO Rep. 2001 Sep;2(9):835-41. doi: 10.1093/embo-reports/kve180. Epub 2001 Aug 23. EMBO Rep. 2001. PMID: 11520861 Free PMC article.
-
The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain.Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1365-70. doi: 10.1073/pnas.032395699. Epub 2002 Jan 22. Proc Natl Acad Sci U S A. 2002. PMID: 11805291 Free PMC article.
-
Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.J Biol Chem. 2001 Nov 23;276(47):43756-60. doi: 10.1074/jbc.C100410200. Epub 2001 Oct 2. J Biol Chem. 2001. PMID: 11583985
-
Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.Exp Gerontol. 2000 Jul;35(4):453-60. doi: 10.1016/s0531-5565(00)00111-x. Exp Gerontol. 2000. PMID: 10959033 Review.
Cited by
-
Cycle on Wheels: Is APP Key to the AppBp1 Pathway?Austin Alzheimers Parkinsons Dis. 2014;1(2):id1008. Austin Alzheimers Parkinsons Dis. 2014. PMID: 25568892 Free PMC article.
-
γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid β-Protein Production.Int J Alzheimers Dis. 2012;2012:591392. doi: 10.1155/2012/591392. Epub 2012 Dec 31. Int J Alzheimers Dis. 2012. PMID: 23346458 Free PMC article.
-
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.EMBO J. 2002 Oct 15;21(20):5408-16. doi: 10.1093/emboj/cdf541. EMBO J. 2002. PMID: 12374741 Free PMC article.
-
Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.PLoS One. 2006 Dec 20;1(1):e51. doi: 10.1371/journal.pone.0000051. PLoS One. 2006. PMID: 17183681 Free PMC article.
-
Gamma-secretase: substrates and inhibitors.Mol Neurobiol. 2002 Aug;26(1):81-95. doi: 10.1385/MN:26:1:081. Mol Neurobiol. 2002. PMID: 12392058
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
