Review
doi: 10.1016/s1367-5931(00)00223-4.
Protein tyrosine phosphatases: prospects for therapeutics
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- PMID: 11470605
- DOI: 10.1016/s1367-5931(00)00223-4
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Review
Protein tyrosine phosphatases: prospects for therapeutics
Curr Opin Chem Biol.
2001 Aug.
Abstract
Protein tyrosine phosphatases (PTPs) form a large family of enzymes that serve as key regulatory components in signal transduction pathways. Recent gene knockout studies in mice identify PTP1B as a promising target for anti-diabetes/obesity drug discovery. PTPs are also implicated in a wide variety of other disorders, including cancer. Significant progress has been made in identifying small molecules that simultaneously bind both the active site and a unique adjacent site that enables specific inhibition of individual PTP isoenzymes. As a consequence, there are compelling reasons to believe that PTP inhibitors may ultimately serve as powerful therapeutic weapons in our arsenal for battling human diseases.
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