Review
doi: 10.1152/physiologyonline.2001.16.3.106.
Polyamines: new cues in cellular signal transduction
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- PMID: 11443226
- DOI: 10.1152/physiologyonline.2001.16.3.106
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Review
Polyamines: new cues in cellular signal transduction
News Physiol Sci.
2001 Jun.
Abstract
The naturally occurring polyamines putrescine, spermidine, and spermine are involved in signal transduction. This has been demonstrated by using inhibitors for polyamine biosynthesis (such as alpha-difluoromethylornithine) or adding polyamines to cultured cells. Different polyamines, preferentially activated protein kinases (tyrosine kinases and MAP kinases), stimulated the expression of nuclear protooncogenes (myc, jun, and fos).
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