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Review
. 2001;7(1):6-13.
doi: 10.1007/BF03032598.

Molecular genetic abnormalities in the pathogenesis of human lung cancer

E Forgacs  1 , S Zöchbauer-Müller, E Oláh, J D Minna
Affiliations
Free article
Review

Molecular genetic abnormalities in the pathogenesis of human lung cancer

E Forgacs et al. Pathol Oncol Res. 2001.
Free article

Abstract

In the past few years our knowledge of the molecular pathogenesis of lung cancer has significantly increased. There are several molecular mechanisms involved in the multistage carcinogenesis through which respiratory epithelial cells become preneoplastic and then invasive cancer. In this review we summarize some of these changes including, genomic alterations such as loss of heterozygosity and microsatellite alterations, autocrine-paracrine loops, alterations in oncogenes and tumor suppressor genes, tumor angiogenesis, aberrant promoter methylation and inherited predisposition to lung cancer. Translation of these findings to the clinic is also discussed.

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