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. 2001 Apr;30(1):183-96.
doi: 10.1016/s0896-6273(01)00272-0.

Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming

A Betz  1 , P Thakur, H J Junge, U Ashery, J S Rhee, V Scheuss, C Rosenmund, J Rettig, N Brose
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Free article

Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming

A Betz et al. Neuron. 2001 Apr.
Free article

Abstract

Synaptic neurotransmitter release is restricted to active zones, where the processes of synaptic vesicle tethering, priming to fusion competence, and Ca2+-triggered fusion are taking place in a highly coordinated manner. We show that the active zone components Munc13-1, an essential vesicle priming protein, and RIM1, a Rab3 effector with a putative role in vesicle tethering, interact functionally. Disruption of this interaction causes a loss of fusion-competent synaptic vesicles, creating a phenocopy of Munc13-1-deficient neurons. RIM1 binding and vesicle priming are mediated by two distinct structural modules of Munc13-1. The Munc13-1/RIM1 interaction may create a functional link between synaptic vesicle tethering and priming, or it may regulate the priming reaction itself, thereby determining the number of fusion-competent vesicles.

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