Review
doi: 10.1038/35073648.
The dynamics of CD4+ T-cell depletion in HIV disease
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- PMID: 11309627
- DOI: 10.1038/35073648
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Review
The dynamics of CD4+ T-cell depletion in HIV disease
Nature.
.
Abstract
The size and composition of the CD4+ T-cell population is regulated by balanced proliferation of progenitor cells and death of mature progeny. After infection with the human immunodeficiency virus, this homeostasis is often disturbed and CD4+ T cells are instead depleted. Such depletion cannot result simply from accelerated destruction of mature CD4+ T cells - sources of T-cell production must also fail. Ironically, this failure may be precipitated by physiological mechanisms designed to maintain homeostasis in the face of accelerated T-cell loss.
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