Network of vascular-associated dendritic cells in intima of healthy young individuals
- PMID: 11304464
- DOI: 10.1161/01.atv.21.4.503
Network of vascular-associated dendritic cells in intima of healthy young individuals
Abstract
In earlier studies, our group has established a new "immunological" hypothesis for atherogenesis supported by experimental and clinical studies showing that inflammatory immunological reactions against heat shock protein 60 initiate the development of atherosclerosis. In the present study, we describe the discovery of a so-far-unknown network of dendritic cells in the innermost layer of arteries, the intima, but not veins of healthy humans and rabbits. The number of these dendritic cells is comparable to that of Langerhans cells in the skin, and dendritic cells show a similar phenotype (CD1a(+) S-100(+) lag(+) CD31(-) CD83(-) CD86(-) and no staining for von Willebrand factor or smooth muscle cell myosin). These vascular-associated dendritic cells accumulate most densely in those arterial regions that are subjected to major hemodynamic stress by turbulent flow conditions and are known to be predisposed for the later development of atherosclerosis. These results open new perspectives for the activation of the immune system within the arterial wall.
Similar articles
-
Vascular dendritic cells and atherosclerosis.Pathol Res Pract. 1996 May;192(5):462-7. Pathol Res Pract. 1996. PMID: 8832751
-
Resident intimal dendritic cells and the initiation of atherosclerosis.Curr Opin Lipidol. 2010 Oct;21(5):397-403. doi: 10.1097/MOL.0b013e32833ded96. Curr Opin Lipidol. 2010. PMID: 20720490 Review.
-
Dendritic cells in the arterial wall express C1q: potential significance in atherogenesis.Cardiovasc Res. 2003 Oct 15;60(1):175-86. doi: 10.1016/s0008-6363(03)00345-6. Cardiovasc Res. 2003. PMID: 14522421
-
Expression of heat shock protein-70 by dendritic cells in the arterial intima and its potential significance in atherogenesis.J Vasc Surg. 2002 Feb;35(2):368-75. doi: 10.1067/mva.2002.121067. J Vasc Surg. 2002. PMID: 11854737
-
[The role of the blood monocytes in atherogenesis].Tsitol Genet. 1999 Jan-Feb;33(1):70-80. Tsitol Genet. 1999. PMID: 10330698 Review. Russian.
Cited by
-
Functional role of dendritic cells in patients with unstable angina.J Huazhong Univ Sci Technolog Med Sci. 2005;25(4):397-9, 415. doi: 10.1007/BF02828206. J Huazhong Univ Sci Technolog Med Sci. 2005. PMID: 16196286
-
Atherosclerosis: current pathogenesis and therapeutic options.Nat Med. 2011 Nov 7;17(11):1410-22. doi: 10.1038/nm.2538. Nat Med. 2011. PMID: 22064431 Review.
-
Generation of Adducts of 4-Hydroxy-2-nonenal with Heat Shock 60 kDa Protein 1 in Human Promyelocytic HL-60 and Monocytic THP-1 Cell Lines.Oxid Med Cell Longev. 2015;2015:296146. doi: 10.1155/2015/296146. Epub 2015 May 20. Oxid Med Cell Longev. 2015. PMID: 26078803 Free PMC article.
-
Tanshinone II A inhibits dendritic cell-mediated adaptive immunity: potential role in anti-atherosclerotic activity.Chin J Integr Med. 2014 Oct;20(10):764-9. doi: 10.1007/s11655-012-1213-9. Epub 2012 Sep 21. Chin J Integr Med. 2014. PMID: 23001464
-
Myeloid cells in atherosclerosis: initiators and decision shapers.Semin Immunopathol. 2009 Jun;31(1):35-47. doi: 10.1007/s00281-009-0141-z. Epub 2009 Feb 24. Semin Immunopathol. 2009. PMID: 19238385 Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials