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Review
. 2001 Apr;57(4 Suppl 1):143-7.
doi: 10.1016/s0090-4295(00)00961-4.

Angiogenesis as a potential biomarker in prostate cancer chemoprevention trials

I U Ali  1 , D R Senger, L E Smith
Affiliations
Review

Angiogenesis as a potential biomarker in prostate cancer chemoprevention trials

I U Ali et al. Urology. 2001 Apr.

Abstract

Prostate cancer is a multistep process in which progression rather than initiation may be the rate-limiting step. A strong possibility is that prostatic intraepithelial neoplasia lesions that switch to angiogenic phenotype eventually progress to cancer. However, it is a challenging task to quantitate angiogenesis in preneoplastic lesions. A promising approach to measuring angiogenesis involves real-time TaqMan polymerase chain reaction to quantitate mRNAs encoding a panel of angiogenesis markers. This highly sensitive molecular technique has potential for quantitating angiogenesis in clinical settings and can be used as a high-throughput screening procedure in prostate cancer clinical trials.

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