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. 1978 Nov-Dec;129 B(4):537-49.

Pleiotropic control mutations affecting the sporulation of Bacillus subtilis

  • PMID: 112899

Pleiotropic control mutations affecting the sporulation of Bacillus subtilis

G Balassa et al. Ann Microbiol (Paris). 1978 Nov-Dec.

Abstract

Mutations affecting quantitatively the production of the sporulation-associated extracellular alkaline protease were isolated and characterized. They fall into at least five genes, three of which, ScoA, B and C, were mapped in the argC-metC region. The pleiotropic effects of these mutations concern several or all of the following: rate and timing of protease production, synthesis of alkaline phosphatase, time-course of spore formation. Electron microscopic evidence indicates delayed switch from one morphological stage to another. The nature of the Sco mutations and the genetic regulation of sporulation are discussed.

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