Regulation of phagocytosis and endo-phagosomal trafficking pathways in Dictyostelium discoideum
- PMID: 11257434
- DOI: 10.1016/s0304-4165(01)00106-4
Regulation of phagocytosis and endo-phagosomal trafficking pathways in Dictyostelium discoideum
Abstract
Phagocytosis, a critically important process employed by leukocytes against invading pathogens, is an actin-dependent clathrin-independent process that results in the internalization of particles >0.5 microm in diameter. Phagocytosis consists of a number of stages, including the binding of particles to the cell surface via interaction with a receptor, engulfment of the particle by pseudopod extension, and fission and fusion reactions to form phago-lysosomes. Much remains to be learned concerning the molecular mechanisms that regulate particle internalization and phagosome maturation. Dictyostelium is a genetically tractable professional phagocyte that has proven useful in determining the molecular steps involved in these processes. We will summarize, in this chapter, what we currently understand concerning the molecular mechanisms that regulate the process of phagocytosis in Dictyostelium, and we will compare and contrast this body of information with that available describing phagocytosis in higher organisms. We will also present current information that suggests that macropinocytosis, a process morphologically similar to phagocytosis, utilizes a different signaling pathway than phagocytosis. Finally, we will discuss the process of maturation of phagosomes, which requires membrane trafficking events, and we will summarize data that support the use of Dictyostelium as a model to determine how intracellular pathogens survive.
Similar articles
-
Phagocytosis and macropinocytosis in Dictyostelium: phosphoinositide-based processes, biochemically distinct.Traffic. 2001 May;2(5):311-20. doi: 10.1034/j.1600-0854.2001.002005311.x. Traffic. 2001. PMID: 11350627 Review.
-
The regulation of phagosome maturation in Dictyostelium.J Muscle Res Cell Motil. 2002;23(7-8):803-8. doi: 10.1023/a:1024435913949. J Muscle Res Cell Motil. 2002. PMID: 12952078 Review.
-
The endocytic pathways of Dictyostelium discoideum.Int J Dev Biol. 2019;63(8-9-10):461-471. doi: 10.1387/ijdb.190236jk. Int J Dev Biol. 2019. PMID: 31840784 Review.
-
A class VII unconventional myosin is required for phagocytosis.Curr Biol. 1999 Nov 18;9(22):1297-303. doi: 10.1016/s0960-9822(00)80051-2. Curr Biol. 1999. PMID: 10574761
-
Visualizing Key Signaling Components of Macropinocytosis and Phagocytosis Using Confocal Microscopy in the Model Organism Dictyostelium discoideum.Methods Mol Biol. 2021;2304:193-205. doi: 10.1007/978-1-0716-1402-0_10. Methods Mol Biol. 2021. PMID: 34028718
Cited by
-
Dictyostelium LvsB has a regulatory role in endosomal vesicle fusion.J Cell Sci. 2014 Oct 15;127(Pt 20):4356-67. doi: 10.1242/jcs.138123. Epub 2014 Aug 1. J Cell Sci. 2014. PMID: 25086066 Free PMC article.
-
Dictyostelium discoideum RabS and Rab2 colocalize with the Golgi and contractile vacuole system and regulate osmoregulation.J Biosci. 2016 Jun;41(2):205-17. doi: 10.1007/s12038-016-9610-4. J Biosci. 2016. PMID: 27240981
-
Morphology and dynamics of the endocytic pathway in Dictyostelium discoideum.Mol Biol Cell. 2002 Apr;13(4):1390-407. doi: 10.1091/mbc.01-08-0392. Mol Biol Cell. 2002. PMID: 11950947 Free PMC article.
-
Characterizing the Type 6 Secretion System (T6SS) and its role in the virulence of avian pathogenic Escherichia coli strain APECO18.PeerJ. 2021 Dec 17;9:e12631. doi: 10.7717/peerj.12631. eCollection 2021. PeerJ. 2021. PMID: 35003930 Free PMC article.
-
Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium.BMC Genomics. 2008 Jun 17;9:291. doi: 10.1186/1471-2164-9-291. BMC Genomics. 2008. PMID: 18559084 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
