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. 2001 Mar;305(1-2):75-80.
doi: 10.1016/s0009-8981(00)00422-8.

Antioxidant enzyme activities and malondialdehyde levels related to aging

M E Inal  1 , G Kanbak, E Sunal
Affiliations

Antioxidant enzyme activities and malondialdehyde levels related to aging

M E Inal et al. Clin Chim Acta. 2001 Mar.

Abstract

Background: Free oxygen radicals have been proposed as important causative agents of aging. We have evaluated age-related changes in antioxidant enzyme activities and lipid peroxidation.

Methods: We measured erythrocyte superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and plasma malondialdehyde (MDA) levels. One hundred and seventy six healthy subjects were divided into five groups: Group 1 (n = 25; 0.2-1 year-old), Group 2 (n = 28; 2-11 years), Group 3 (n = 23: 12-24 years), Group 4 (n = 40; 25-40 years), Group 5 (n = 60: 41-69 years).

Results: SOD activities in Group 5 were significantly lower than in the other groups (P < 0.001). GPx and CAT activities and MDA levels in Group 5 were significantly higher than the other groups (P < 0.001, respectively). CAT activity in Group 4 was significantly higher than group 1 and group 2 (respectively, P < 0.001), and in group 3 was high compared to Group 2 (P < 0.001). There were negative correlations between SOD activities and age (P < 0.001). Conversely, there were positive correlations between CAT, GPx and MDA levels and age (P < 0.001). CAT activities of women in Group 2 were found to be high compared to the men (P < 0.05). MDA levels of women in Group 5 were higher than in the male groups (P < 0.001).

Conclusions: We found age-related differences in erythrocyte antioxidant enzyme activities. Furthermore, peroxidative injury is raised in the aging process.

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