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. 2001 Mar;7(3):344-9.
doi: 10.1038/85493.

MHC-I-restricted presentation of HIV-1 virion antigens without viral replication

F Buseyne  1 , S Le Gall, C Boccaccio, J P Abastado, J D Lifson, L O Arthur, Y Rivière, J M Heard, O Schwartz
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MHC-I-restricted presentation of HIV-1 virion antigens without viral replication

F Buseyne et al. Nat Med. 2001 Mar.

Abstract

Dendritic cells and macrophages can process extracellular antigens for presentation by MHC-I molecules. This exogenous pathway may have a crucial role in the activation of CD8+ cytotoxic T lymphocytes during human viral infections. We show here that HIV-1 epitopes derived from incoming virions are presented through the exogenous MHC-I pathway in primary human dendritic cells, and to a lower extent in macrophages, leading to cytotoxic T-lymphocyte activation in the absence of viral protein synthesis. Exogenous antigen presentation required adequate virus-receptor interactions and fusion of viral and cellular membranes. These results provide new insights into how anti-HIV cytotoxic T lymphocytes can be activated and have implications for anti-HIV vaccine design.

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