Review
doi: 10.1034/j.1600-0854.2000.010902.x.
Biogenesis of the sorting endosome: the role of Rab5
Affiliations
- PMID: 11208157
- DOI: 10.1034/j.1600-0854.2000.010902.x
Item in Clipboard
Review
Biogenesis of the sorting endosome: the role of Rab5
Traffic.
2000 Sep.
Free article
Abstract
Rab5 is a regulatory guanosine triphosphatase that is associated with the sorting endosome and participates in endosomal membrane fusion reactions. Recent experiments have provided insights into Rab5 function by demonstrating direct links between Rab5-interacting proteins and components of the membrane fusion apparatus. In addition, a realisation that Rab5 has additional functions in endosome biogenesis is emerging. These advances may be profoundly important in changing the way that we view the sorting endosome and in developing models that properly reflect the dynamic qualities of the endocytic pathway.
Similar articles
-
A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion.J Biol Chem. 2000 Aug 11;275(32):24661-9. doi: 10.1074/jbc.M909600199. J Biol Chem. 2000. PMID: 10818110
-
Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex.J Cell Biol. 2003 Jul 7;162(1):125-37. doi: 10.1083/jcb.200302083. J Cell Biol. 2003. PMID: 12847087 Free PMC article.
-
Arf6-independent GPI-anchored protein-enriched early endosomal compartments fuse with sorting endosomes via a Rab5/phosphatidylinositol-3'-kinase-dependent machinery.Mol Biol Cell. 2006 Aug;17(8):3689-704. doi: 10.1091/mbc.e05-10-0980. Epub 2006 Jun 7. Mol Biol Cell. 2006. PMID: 16760436 Free PMC article.
-
Membrane tethering and fusion in the secretory and endocytic pathways.Traffic. 2000 Aug;1(8):588-97. doi: 10.1034/j.1600-0854.2000.010802.x. Traffic. 2000. PMID: 11208146 Review.
-
SNARE protein structure and function.Annu Rev Cell Dev Biol. 2003;19:493-517. doi: 10.1146/annurev.cellbio.19.110701.155609. Annu Rev Cell Dev Biol. 2003. PMID: 14570579 Review.
Cited by
-
TOR complex 2 is a master regulator of plasma membrane homeostasis.Biochem J. 2022 Sep 30;479(18):1917-1940. doi: 10.1042/BCJ20220388. Biochem J. 2022. PMID: 36149412 Free PMC article.
-
Regulation of endocytosis via the oxygen-sensing pathway.Nat Med. 2009 Mar;15(3):319-24. doi: 10.1038/nm.1922. Epub 2009 Mar 1. Nat Med. 2009. PMID: 19252501
-
Insights into acidosis-induced regulation of SLC26A4 (pendrin) and SLC4A9 (AE4) transporters using three-dimensional morphometric analysis of β-intercalated cells.Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F601-11. doi: 10.1152/ajprenal.00404.2013. Epub 2014 Jul 2. Am J Physiol Renal Physiol. 2014. PMID: 24990900 Free PMC article.
-
Redirecting Vesicular Transport to Improve Nonviral Delivery of Molecular Cargo.Adv Biosyst. 2020 Aug;4(8):e2000059. doi: 10.1002/adbi.202000059. Epub 2020 Jul 21. Adv Biosyst. 2020. PMID: 33179869 Free PMC article.
-
Human rhinovirus type 2 is internalized by clathrin-mediated endocytosis.J Virol. 2003 May;77(9):5360-9. doi: 10.1128/jvi.77.9.5360-5369.2003. J Virol. 2003. PMID: 12692238 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
