Lipid membrane domains in cell surface and vacuolar systems
- PMID: 11201787
- DOI: 10.1023/a:1026528921085
Lipid membrane domains in cell surface and vacuolar systems
Abstract
Detergent insoluble sphingolipid-cholesterol enriched 'raft'-like membrane microdomains have been implicated in a variety of biological processes including sorting, trafficking, and signaling. Mutant cells and knockout animals of sphingolipid biosynthesis are clearly useful to understand the biological roles of lipid components in raft-like domains. It is suggested that raft-like domains distribute in internal vacuolar membranes as well as plasma membranes. In addition to sphingolipid-cholesterol-rich membrane domains, recent studies suggest the existence of another lipid-membrane domain in the endocytic pathway. This domain is enriched with a unique phospholipid, lysobisphosphatidic acid (LBPA) and localized in the internal membrane of multivesicular endosome. LBPA-rich membrane domains are involved in lipid and protein sorting within the endosomal system. Possible interaction between sphingolipids and LBPA in sphingolipid-storage disease is discussed.
Similar articles
-
Sphingolipid trafficking and protein sorting in epithelial cells.FEBS Lett. 2002 Oct 2;529(1):54-9. doi: 10.1016/s0014-5793(02)03183-6. FEBS Lett. 2002. PMID: 12354613 Review.
-
Yeast membrane lipid imbalance leads to trafficking defects toward the Golgi.Cell Biol Int. 2018 Jul;42(7):890-902. doi: 10.1002/cbin.10956. Epub 2018 Apr 19. Cell Biol Int. 2018. PMID: 29500884
-
Generation of lipid polarity in intestinal epithelial (Caco-2) cells: sphingolipid synthesis in the Golgi complex and sorting before vesicular traffic to the plasma membrane.J Cell Biol. 1990 Sep;111(3):977-86. doi: 10.1083/jcb.111.3.977. J Cell Biol. 1990. PMID: 2391372 Free PMC article.
-
Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids.Annu Rev Cell Dev Biol. 2005;21:81-103. doi: 10.1146/annurev.cellbio.21.122303.120013. Annu Rev Cell Dev Biol. 2005. PMID: 16212488 Review.
-
Fluorescent analogues of plasma membrane sphingolipids are sorted to different intracellular compartments in astrocytes; Harmful effects of chronic ethanol exposure on sphingolipid trafficking and metabolism.FEBS Lett. 2004 Apr 9;563(1-3):59-65. doi: 10.1016/S0014-5793(04)00245-5. FEBS Lett. 2004. PMID: 15063723
Cited by
-
Cellular Lipids-Hijacked Victims of Viruses.Viruses. 2022 Aug 27;14(9):1896. doi: 10.3390/v14091896. Viruses. 2022. PMID: 36146703 Free PMC article. Review.
-
Neurobiology and cellular pathogenesis of glycolipid storage diseases.Philos Trans R Soc Lond B Biol Sci. 2003 May 29;358(1433):893-904. doi: 10.1098/rstb.2003.1276. Philos Trans R Soc Lond B Biol Sci. 2003. PMID: 12803923 Free PMC article. Review.
-
Morphological changes of supported lipid bilayers induced by lysozyme: planar domain formation vs. multilayer stacking.Colloids Surf B Biointerfaces. 2010 Oct 15;80(2):219-26. doi: 10.1016/j.colsurfb.2010.06.011. Epub 2010 Jun 25. Colloids Surf B Biointerfaces. 2010. PMID: 20620034 Free PMC article.
-
Regulation of sterol transport between membranes and NPC2.Biochemistry. 2008 Oct 21;47(42):11134-43. doi: 10.1021/bi801328u. Epub 2008 Sep 30. Biochemistry. 2008. PMID: 18823126 Free PMC article.
-
Gangliosides are not essential for influenza virus infection.Glycoconj J. 2006 Feb;23(1-2):107-13. doi: 10.1007/s10719-006-5443-y. Glycoconj J. 2006. PMID: 16575528
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources