Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures
- PMID: 11182468
- DOI: 10.1016/s0197-4580(00)00235-9
Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures
Abstract
Accumulating evidence implicates oxidative stress in the pathogenesis of several neurodegenerative diseases including Alzheimer's disease (AD). Increased lipid peroxidation, decreased levels of polyunsaturated fatty acids, and increased levels of 4-hydroxynonenal (HNE), F(2)-isoprostanes, and F(4)-neuroprostanes are present in the brain in AD. Acrolein, an alpha,beta-unsaturated aldehydic product of lipid peroxidation, is approximately 100 times more reactive than HNE and recently was demonstrated in neurofibrillary tangles in the brain in AD. In three brain regions of 10 AD patients compared with 8 age-matched control subjects, we found increased mean extractable acrolein, with the increases reaching statistical significance in the amygdala and hippocampus/parahippocampal gyrus. In hippocampal neuron cultures, acrolein was neurotoxic in a time- and concentration-dependent manner and more toxic than HNE at 5 microM concentrations of each. Acrolein exposure led to a significant concentration-dependent increase in intracellular calcium concentrations. Collectively, these data show that acrolein is increased in the brain in AD and demonstrate neurotoxicity mechanisms that might be important in the pathogenesis of neuron degeneration in AD.
Comment in
-
Could carnosine be a naturally-occurring scavenger for acrolein and other reactive aldehydes in the brain?Neurobiol Aging. 2002 Jul-Aug;23(4):645-6. doi: 10.1016/s0197-4580(02)00006-4. Neurobiol Aging. 2002. PMID: 12009514 No abstract available.
Similar articles
-
Acrolein, a product of lipid peroxidation, inhibits glucose and glutamate uptake in primary neuronal cultures.Free Radic Biol Med. 2000 Oct 15;29(8):714-20. doi: 10.1016/s0891-5849(00)00346-4. Free Radic Biol Med. 2000. PMID: 11053772
-
Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease.J Neurochem. 1999 Feb;72(2):751-6. doi: 10.1046/j.1471-4159.1999.0720751.x. J Neurochem. 1999. PMID: 9930749
-
Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease.Neurobiol Aging. 2006 Aug;27(8):1094-9. doi: 10.1016/j.neurobiolaging.2005.06.004. Epub 2005 Jul 1. Neurobiol Aging. 2006. PMID: 15993986
-
Role of by-products of lipid oxidation in Alzheimer's disease brain: a focus on acrolein.J Alzheimers Dis. 2010;21(3):741-56. doi: 10.3233/JAD-2010-100405. J Alzheimers Dis. 2010. PMID: 20634576 Review.
-
Potential role of acrolein in neurodegeneration and in Alzheimer's disease.Curr Mol Pharmacol. 2010 Jun;3(2):66-78. Curr Mol Pharmacol. 2010. PMID: 20302565 Review.
Cited by
-
Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury.J Neurochem. 2016 Jul;138(2):328-38. doi: 10.1111/jnc.13639. Epub 2016 May 16. J Neurochem. 2016. PMID: 27060873 Free PMC article.
-
Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal.Toxicol Appl Pharmacol. 2012 Sep 15;263(3):303-14. doi: 10.1016/j.taap.2012.07.002. Epub 2012 Jul 20. Toxicol Appl Pharmacol. 2012. PMID: 22819785 Free PMC article.
-
Electrophilic cyclopentenone isoprostanes in neurodegeneration.J Mol Neurosci. 2007 Sep;33(1):80-6. doi: 10.1007/s12031-007-0042-3. J Mol Neurosci. 2007. PMID: 17901550 Free PMC article. Review.
-
Redox signaling at the crossroads of human health and disease.MedComm (2020). 2022 Mar 31;3(2):e127. doi: 10.1002/mco2.127. eCollection 2022 Jun. MedComm (2020). 2022. PMID: 35386842 Free PMC article. Review.
-
The Involvement of Polyamines Catabolism in the Crosstalk between Neurons and Astrocytes in Neurodegeneration.Biomedicines. 2022 Jul 21;10(7):1756. doi: 10.3390/biomedicines10071756. Biomedicines. 2022. PMID: 35885061 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
