Review
doi: 10.1006/smim.2000.0273.
Diverse CD1d-restricted T cells: diverse phenotypes, and diverse functions
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- PMID: 11145861
- DOI: 10.1006/smim.2000.0273
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Review
Diverse CD1d-restricted T cells: diverse phenotypes, and diverse functions
Semin Immunol.
2000 Dec.
Abstract
Invariant CD1d-restricted T cells express NK cell markers and use a limited TCR repertoire. Here, we describe a second CD1d-restricted T cell subset that uses a diverse TCR repertoire. These T cells can also express NK cell markers and function similarly to invariant T cells. The antigens recognized by the diverse subset are likely to be different from those recognized by invariant TCRs. The variable NK1.1 antigen expression on these T cell populations limits its usefulness in identifying CD1d-restricted T cells. Lastly, the discovery of antigens recognized by diverse CD1d-restricted T cells will provide insight into their role in normal and pathological immune responses.
Copyright 2000 Academic Press.
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