Vertical transmission of hepatitis B antigen in Taiwan
- PMID: 1113797
- DOI: 10.1056/NEJM197504102921503
Vertical transmission of hepatitis B antigen in Taiwan
Abstract
To determine the frequency of vertical transmission of hepatitis B antigen (HB5 Ag) from asymptomatic carrier mothers in Taiwan to their offspring, HB5 Ag was sought by radioimmunoassay and complement fixation. Of 158 babies born to carrier mothers, antigenemia developed in 63; 51 of these antigenemic babies had become antigen positive within the six months of life. Three inter-related factors were found to increase the risk that antigenemia would develop in the infant: a high maternal complement-fixation titer for HB5 Ag: presence of HB5 Ag in the baby's umbilical-cord blood: and antigenemia in siblings. In contrast to previous studies, these findings indicate that vertical transmission from carrier mothers frequently occurs, at least in Taiwan, and may partially explain Taiwan's high prevalence of HB5 Ag.
Similar articles
-
e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants.N Engl J Med. 1976 Apr 1;294(14):746-9. doi: 10.1056/NEJM197604012941402. N Engl J Med. 1976. PMID: 943694
-
Hepatitis B antigen in infants born to mothers with chronic hepatitis B antigenemia in Taiwan.Am J Dis Child. 1975 Dec;129(12):1389-92. doi: 10.1001/archpedi.1975.02120490007003. Am J Dis Child. 1975. PMID: 1199980
-
Vertical transmission of the hepatitis B surface antigen in Thailand.Southeast Asian J Trop Med Public Health. 1980 Dec;11(4):582-7. Southeast Asian J Trop Med Public Health. 1980. PMID: 7221701
-
Vertical transmission of hepatitis-B surface antigen.Biomedicine. 1977 Feb;26(1):12-5. Biomedicine. 1977. PMID: 324529 Review.
-
Hepatitis B virus infection.Semin Fetal Neonatal Med. 2007 Jun;12(3):160-7. doi: 10.1016/j.siny.2007.01.013. Epub 2007 Feb 28. Semin Fetal Neonatal Med. 2007. PMID: 17336170 Review.
Cited by
-
Vertical transmission of hepatitis B surface antigen in carrier mothers in two west London hospitals.Arch Dis Child. 1979 Sep;54(9):670-5. doi: 10.1136/adc.54.9.670. Arch Dis Child. 1979. PMID: 518104 Free PMC article.
-
Intrahepatic cholestasis of pregnancy with marked elevation of transaminases in a black American.Dig Dis Sci. 1987 Jun;32(6):665-8. doi: 10.1007/BF01296169. Dig Dis Sci. 1987. PMID: 3568954
-
Insights into Thymus Development and Viral Thymic Infections.Viruses. 2019 Sep 9;11(9):836. doi: 10.3390/v11090836. Viruses. 2019. PMID: 31505755 Free PMC article. Review.
-
Long-term follow-up of Hepatitis B Surface antibody levels in subjects receiving universal Hepatitis B vaccination in infancy in an area of hyperendemicity: correlation between radioimmunoassay and enzyme immunoassay.Clin Diagn Lab Immunol. 2005 Dec;12(12):1442-7. doi: 10.1128/CDLI.12.12.1442-1447.2005. Clin Diagn Lab Immunol. 2005. PMID: 16339069 Free PMC article.
-
Age-related differences in amplification of covalently closed circular DNA at early times after duck hepatitis B virus infection of ducks.J Virol. 2005 Aug;79(15):9896-903. doi: 10.1128/JVI.79.15.9896-9903.2005. J Virol. 2005. PMID: 16014950 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
