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. 2001 Jan-Feb;16(1):13-7.
doi: 10.1159/000053873.

In utero hematopoietic stem cell transplantation: a caprine model for prenatal therapy in inherited metabolic diseases

K L Lovell  1 , S A Kraemer, J R Leipprandt, D J Sprecher, N K Ames, J Nichols-Torrez, K D Carter, D K Rahmani, M Z Jones
Affiliations

In utero hematopoietic stem cell transplantation: a caprine model for prenatal therapy in inherited metabolic diseases

K L Lovell et al. Fetal Diagn Ther. 2001 Jan-Feb.

Abstract

Objectives: We explored the feasibility and efficacy of in utero hematopoietic stem cell transplantation in the caprine animal model system with the objectives of determining procedures for transplantation and establishing methods for detecting engraftment.

Methods: Male fetal liver hematopoietic stem cells were injected into female fetuses during the immunotolerant period, using either hysterotomy or ultrasound-guided injections.

Results: The rate of fetal death was much lower for the ultrasound-guided injections. Donor cells were observed in the peritoneal fluid of 4 fetuses 3 days after injection, but no donor cells were detected in tissues at longer time periods.

Conclusions: Ultrasound-guided injection of hematopoietic stem cells into the abdomen of a developing fetus is safe and feasible. The parameters required for successful engraftment have not yet been identified.

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