Review
doi: 10.1006/scdb.2000.0188.
Role of Cbfa1 in osteoblast differentiation and function
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- PMID: 11105898
- DOI: 10.1006/scdb.2000.0188
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Review
Role of Cbfa1 in osteoblast differentiation and function
Semin Cell Dev Biol.
2000 Oct.
Abstract
Among the multiple cell lineages whose differentiation is affected by a runt-related gene the osteoblast is a relative newcomer. Molecular biology, developmental biology and mouse and human genetic studies have demonstrated that Cbfa1 is a critical regulator of osteoblast differentiation in vertebrates. Cbfa1 is not only a differentiation factor but also a regulator of bone formation by differentiated osteoblasts beyond development. Thus, Cbfa1 controls osteogenesis at multiple stages.
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