In search of an enzyme: the beta-secretase of Alzheimer's disease is an aspartic proteinase
- PMID: 11074266
- DOI: 10.1016/s0166-2236(00)01647-7
In search of an enzyme: the beta-secretase of Alzheimer's disease is an aspartic proteinase
Abstract
The deposition of beta-amyloid (Abeta) in the brain is a neuropathological feature of Alzheimer's disease. Abeta is cleaved from its precursor protein (APP) by processing at its N and C termini by enzymes known as beta- and gamma-secretases,respectively. The identity of these enzymes has been elusive but the search for the N-terminal secretase might have ended recently with the almost simultaneous publication by five major laboratories claiming a transmembrane aspartic proteinase to be the long sought after beta-secretase. Even at this early stage of its characterization, this aspartic proteinase fulfils many of the key criteria necessary for beta-secretase. The race is now on to develop inhibitors that could prove effective in halting the progression of Alzheimer's disease.
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