Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Nov;78(11):830-2.

[The effects of FSH,LH and insulin on steroids production by granulosa cells from polycystic ovaries syndrome]

[Article in Chinese]
A Wang  1 , C Lu, J Qiao
Affiliations
  • PMID: 11038778

[The effects of FSH,LH and insulin on steroids production by granulosa cells from polycystic ovaries syndrome]

[Article in Chinese]
A Wang et al. Zhonghua Yi Xue Za Zhi. 1998 Nov.

Abstract

Objectives: To investigate steroids production of granulosa cells obtained from normal ovaries and polycystic ovaries from polycystic ovary syndrome (PCOS) patients under FSH, LH and insulin stimulation.

Methods: Granulosa cells of 33 folicles from 18 pairs of normal ovaries and about 100 folicles from 8 pairs of PCOS were cultured. Estrodial (E2) and progesterone (P) accumulation in the medium was determined under different incubated conditions by RIA.

Results: Granulosa cells from PCOS produced more E2(P < 0.05-0.01) under basal, FSH and insulin stimulation and more P (P < 0.05-0.01) under FSH, LH and insulin stimulation than controls. Insulin markedly augmented FSH and LH-stimulated steroid accumulation by two groups of granulosa cells. Granulosa cells from PCOS with peripheral insulin resistance also responded to insulin.

Conclusion: Enzymes for steroids synthesis in granulosa cells from PCOS may be activated in vivo, and hyperinsulinisma and elevated LH levels in PCOS may be contributable.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Nuclear receptors and their selective pharmacologic modulators.
    Burris TP, Solt LA, Wang Y, Crumbley C, Banerjee S, Griffett K, Lundasen T, Hughes T, Kojetin DJ. Burris TP, et al. Pharmacol Rev. 2013 Mar 1;65(2):710-78. doi: 10.1124/pr.112.006833. Print 2013 Apr. Pharmacol Rev. 2013. PMID: 23457206 Free PMC article. Review.

Publication types