Comment
doi: 10.1126/science.289.5487.2066.
Biomedicine. Staying slim with insulin in mind
Affiliations
- PMID: 11032558
- DOI: 10.1126/science.289.5487.2066
Item in Clipboard
Comment
Biomedicine. Staying slim with insulin in mind
Science.
.
Abstract
Striking the delicate balance between energy intake in the form of food and energy expenditure in the form of metabolic activity keeps the body extremely busy. As Schwartz explains in his enlightening Perspective, the finding that insulin signals the brain to promote weight loss (Brüning et al.) flies in the face of the notion that insulin is involved solely in glucose storage, its conversion to fat, and weight gain.
Comment on
-
Role of brain insulin receptor in control of body weight and reproduction.Science. 2000 Sep 22;289(5487):2122-5. doi: 10.1126/science.289.5487.2122. Science. 2000. PMID: 11000114
Similar articles
-
Role of brain insulin receptor in control of body weight and reproduction.Science. 2000 Sep 22;289(5487):2122-5. doi: 10.1126/science.289.5487.2122. Science. 2000. PMID: 11000114
-
[Brain regulation of food intake and expenditure energy: molecular action of insulin, leptin and physical exercise].Rev Neurol. 2007 Dec 1-15;45(11):672-82. Rev Neurol. 2007. PMID: 18050100 Review. Spanish.
-
Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis.Exp Biol Med (Maywood). 2001 Dec;226(11):963-77. doi: 10.1177/153537020122601102. Exp Biol Med (Maywood). 2001. PMID: 11743131 Review.
-
Insulin as an adiposity signal.Int J Obes Relat Metab Disord. 2001 Dec;25 Suppl 5:S35-8. doi: 10.1038/sj.ijo.0801909. Int J Obes Relat Metab Disord. 2001. PMID: 11840212 Review.
-
Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight.Brain Res. 1999 Nov 27;848(1-2):114-23. doi: 10.1016/s0006-8993(99)01974-5. Brain Res. 1999. PMID: 10612703 Review.
Cited by
-
Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review.CNS Drugs. 2005;19 Suppl 1:1-93. doi: 10.2165/00023210-200519001-00001. CNS Drugs. 2005. PMID: 15998156 Review.
-
Pro-opiomelanocortin modulates the thermogenic and physical activity responses to high-fat feeding and markedly influences dietary fat preference.Endocrinology. 2007 Nov;148(11):5331-8. doi: 10.1210/en.2007-0797. Epub 2007 Aug 23. Endocrinology. 2007. PMID: 17717049 Free PMC article.
-
Leptin is associated with exaggerated brain reward and emotion responses to food images in adolescent obesity.Diabetes Care. 2014 Nov;37(11):3061-8. doi: 10.2337/dc14-0525. Epub 2014 Aug 19. Diabetes Care. 2014. PMID: 25139883 Free PMC article.
-
Determinants of weight gain in the action to control cardiovascular risk in diabetes trial.Diabetes Care. 2013 Aug;36(8):2162-8. doi: 10.2337/dc12-1391. Epub 2013 Feb 14. Diabetes Care. 2013. PMID: 23412077 Free PMC article. Clinical Trial.
-
Neural correlates of stress- and food cue-induced food craving in obesity: association with insulin levels.Diabetes Care. 2013 Feb;36(2):394-402. doi: 10.2337/dc12-1112. Epub 2012 Oct 15. Diabetes Care. 2013. PMID: 23069840 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
