Butorphanol and pentazocine in patients with severe postoperative pain
- PMID: 1102232
- DOI: 10.1002/cpt1975185part1547
Butorphanol and pentazocine in patients with severe postoperative pain
Abstract
Either butorphanol tartrate (1, 2, or 4 mg) or pentazocine (30 or 60 mg) was given intramuscularly (5 dose groups) to 262 patients, who were scheduled for major operations, if they had severe pain after full awakening in the recovery room, postoperatively under double-blind conditions. There were at least 50 patients in each of the five dosage groups. Pain intensity and relief were scored numerically for each treated patient at 1/2 1, 2, 3 and 4 hr, while under direct surveillance, and the patients were seen again for follow-ups during the first 24 hr postoperatively. Appreciable pain relief developed within 30 min at all dose levels, with a peak analgesic effect apparent at about 1 hr. Satisfactory relief persisted for 4 hr in the majority of patients in each group. With the lowest dose of butorphanol tartrate (1 mg), which gave good pain relief for only 2 to 4 hr, approximately 60% of the patients had to be remedicated within 4 hr. Vital signs were not appreciably affected, but the patients who received the high dose of analgesics (butorphanol tartrate 4 mg or pentazocine lactate 60 mg) were often quite drowsy. The incidence of other side effects was negligible. The relative potency assay showed that butorphanol was approximately 20 times as potent as pentazocine for up to 4 hr.
Similar articles
-
Butorphanol: a double-blind comparison with pentazocine in post-operative patients with moderate to severe pain.J Int Med Res. 1976;4(4):255-64. doi: 10.1177/030006057600400408. J Int Med Res. 1976. PMID: 799996 Clinical Trial.
-
Double-blind placebo controlled oral analgesic comparison of butorphanol andpentazocine in patients with moderate to severe post-operative pain.J Int Med Res. 1977;5(6):422-8. doi: 10.1177/030006057300100207. J Int Med Res. 1977. PMID: 338393 Clinical Trial.
-
Comparison of butorphanol and pentazocine as postoperative analgesics.South Med J. 1979 May;72(5):578-80. doi: 10.1097/00007611-197905000-00020. South Med J. 1979. PMID: 375401 Clinical Trial.
-
Drug therapy reviews: evaluation of butorphanol tartrate.Am J Hosp Pharm. 1979 Dec;36(12):1683-91. Am J Hosp Pharm. 1979. PMID: 393109 Review.
-
Pentazocine analgesia: is there a niche for Talwin Nx?Compendium. 1993 Aug;14(8):1048, 1050 passim; quiz 1060. Compendium. 1993. PMID: 8269439 Review.
Cited by
-
Comparison of analgesia by intravenous butorphanol and meperidine in patients with post-operative pain.Can Anaesth Soc J. 1977 Jan;24(1):90-102. doi: 10.1007/BF03006816. Can Anaesth Soc J. 1977. PMID: 318908 Clinical Trial.
-
Clinical pharmacokinetics of narcotic agonist-antagonist drugs.Clin Pharmacokinet. 1983 Jul-Aug;8(4):332-43. doi: 10.2165/00003088-198308040-00004. Clin Pharmacokinet. 1983. PMID: 6352139 Review. No abstract available.
-
Butorphanol tartrate: 2. Safety and efficacy in balanced anaesthesia.Can Anaesth Soc J. 1976 Nov;23(6):601-8. doi: 10.1007/BF03006742. Can Anaesth Soc J. 1976. PMID: 990976 No abstract available.
-
The effects of age and sex on the systemic availability and pharmacokinetics of transnasal butorphanol.Eur J Clin Pharmacol. 1994;47(1):57-60. doi: 10.1007/BF00193479. Eur J Clin Pharmacol. 1994. PMID: 7988625 Clinical Trial.
-
Analgesic effectiveness of the narcotic agonist-antagonists.Br J Clin Pharmacol. 1979;7 Suppl 3(Suppl 3):297S-308S. doi: 10.1111/j.1365-2125.1979.tb04704.x. Br J Clin Pharmacol. 1979. PMID: 223617 Free PMC article.