Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2000 Oct;1(4):285-9.
doi: 10.1038/79724.

T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock

M D Hazenberg  1 , D Hamann, H Schuitemaker, F Miedema
Affiliations
Review

T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock

M D Hazenberg et al. Nat Immunol. 2000 Oct.

Abstract

HIV-1 infection is characterized by a gradual loss of CD4+ T cells and progressive immune deficiency that leads to opportunistic infections, otherwise rare malignancies and ultimately death. Extensive research over the past two decades has increased our insight into the pathogenic mechanisms underlying these features of HIV-1 infection. Here, we will give a brief overview of the most recent findings and present a model that fits most of the relevant aspects of HIV-1 infection as known. We hypothesize that HIV-1 infection depletes T cell supplies (which are not replaced because of low and static thymic function) by direct infection and killing of cells and through hyperactivation of the immune system.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles