Enteroviruses can persist with or without active viral replication in cardiac tissue of patients with end-stage ischemic or dilated cardiomyopathy
- PMID: 10979922
- DOI: 10.1086/315818
Enteroviruses can persist with or without active viral replication in cardiac tissue of patients with end-stage ischemic or dilated cardiomyopathy
Abstract
To investigate enterovirus replication versus persistence in end-stage cardiac diseases, endomyocardial biopsies from explanted hearts of 70 patients with idiopathic dilated cardiomyopathy (IDCM), 64 patients with chronic coronary disease (CCD), and 45 donors of healthy hearts (controls) were examined by reverse transcriptase-polymerase chain reaction for genomic and antigenomic enterovirus RNA and by VP1 antigen immunohistochemistry. Enterovirus genome was detected in 25 of 70 patients with IDCM and in 21 of 64 patients with CCDs (35.7 vs. 32.8%, respectively; P=.12). Of the 46 patients positive for genomic RNA, only 3 exhibited antigenomic RNA and VP1 antigen that demonstrated active viral replication, whereas 43 had latent infection characterized by the absence of antigenomic RNA associated with or not with VP1 antigen expression. No viral component was detected in control subjects. The findings demonstrate that a small percentage of patients with end-stage chronic cardiac diseases had active enterovirus replication in their myocardium.
Similar articles
-
Detection of enteroviral RNA by polymerase chain reaction in endomyocardial tissue of patients with chronic cardiac diseases.J Med Virol. 1996 Jan;48(1):53-9. doi: 10.1002/(SICI)1096-9071(199601)48:1<53::AID-JMV9>3.0.CO;2-K. J Med Virol. 1996. PMID: 8825711
-
Association between enterovirus endomyocardial infection and late severe cardiac events in some adult patients receiving heart transplants.J Med Virol. 2005 Jan;75(1):47-53. doi: 10.1002/jmv.20236. J Med Virol. 2005. PMID: 15543592
-
Evidence of viral infection in the myocardium of American and Japanese patients with idiopathic dilated cardiomyopathy.Am J Cardiol. 2004 Sep 1;94(5):602-5. doi: 10.1016/j.amjcard.2004.05.023. Am J Cardiol. 2004. PMID: 15342290
-
Enteroviruses and myocarditis.Br J Hosp Med. 1995 May 3-16;53(9):430-4. Br J Hosp Med. 1995. PMID: 7613714 Review.
-
Pathology of cardiac transplantation: recipient hearts (chronic heart failure) and donor hearts (acute and chronic rejection).Mayo Clin Proc. 1992 Jul;67(7):685-96. doi: 10.1016/s0025-6196(12)60726-5. Mayo Clin Proc. 1992. PMID: 1434905 Review.
Cited by
-
5'-Terminal deletions occur in coxsackievirus B3 during replication in murine hearts and cardiac myocyte cultures and correlate with encapsidation of negative-strand viral RNA.J Virol. 2005 Jun;79(11):7024-41. doi: 10.1128/JVI.79.11.7024-7041.2005. J Virol. 2005. PMID: 15890942 Free PMC article.
-
Persistent viral infections and their role in heart disease.Front Microbiol. 2022 Nov 24;13:1030440. doi: 10.3389/fmicb.2022.1030440. eCollection 2022. Front Microbiol. 2022. PMID: 36504781 Free PMC article. Review.
-
5' terminal deletions in the genome of a coxsackievirus B2 strain occurred naturally in human heart.Virology. 2008 Jun 5;375(2):480-91. doi: 10.1016/j.virol.2008.02.030. Epub 2008 Apr 1. Virology. 2008. PMID: 18378272 Free PMC article.
-
Functional Consequences of RNA 5'-Terminal Deletions on Coxsackievirus B3 RNA Replication and Ribonucleoprotein Complex Formation.J Virol. 2017 Jul 27;91(16):e00423-17. doi: 10.1128/JVI.00423-17. Print 2017 Aug 15. J Virol. 2017. PMID: 28539455 Free PMC article.
-
A new monoclonal antibody (Cox mAB 31A2) detects VP1 protein of coxsackievirus B3 with high sensitivity and specificity.Virchows Arch. 2016 Nov;469(5):553-562. doi: 10.1007/s00428-016-2008-8. Epub 2016 Aug 27. Virchows Arch. 2016. PMID: 27566306
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
