Review
doi: 10.1016/s0955-0674(00)00144-7.
PML and the oncogenic nuclear domains in regulating transcriptional repression
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- PMID: 10978902
- DOI: 10.1016/s0955-0674(00)00144-7
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Review
PML and the oncogenic nuclear domains in regulating transcriptional repression
Curr Opin Cell Biol.
2000 Oct.
Abstract
Promyelocytic leukemia protein (PML) is a tumor suppressor involved in the t(15;17) translocation that causes acute promyelocytic leukemia (APL). PML is located at multiple nuclear domains known as PML oncogenic domains (PODs), whose structures are dynamically regulated and disrupted in t(15;17) APL cells. PML is involved in several important cellular processes; however, its exact function is unclear. Recently, a POD-associated protein was found to be transcriptional repressor, suggesting a new role for PODs in regulating transcriptional repression.
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