Nuclear and nucleolar localization of parathyroid hormone-related protein
- PMID: 10947864
- DOI: 10.1046/j.1440-1711.2000.00919.x
Nuclear and nucleolar localization of parathyroid hormone-related protein
Abstract
Parathyroid hormone-related protein (PTHrP) was first discovered as the factor causing hypercalcaemia produced by solid tumours frequently associated with the head and neck, breast, lung and kidney. The homology of its amino-terminus to parathyroid hormone (PTH; eight of the first 13 residues are identical), enables it to share the same receptor and perform similar biological functions to PTH. The sequences of PTHrP C-terminal to its PTH-like region confer functions such as transplacental calcium transport, renal bicarbonate excretion and in vitro osteoclast inhibition. Recent findings have shown that PTHrP is a nuclear/nucleolar protein in certain tissues and that this localization is cell cycle-regulated, mediated by the middle portion of the molecule, and involves the nuclear import receptor importin beta1. The present review discusses what is known about the pathway by which PTHrP localizes to the nucleus/nucleolus and the putative roles it may have there.
Similar articles
-
Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles.Vitam Horm. 2003;66:345-84. doi: 10.1016/s0083-6729(03)01010-0. Vitam Horm. 2003. PMID: 12852260 Review.
-
Molecular dissection of the importin beta1-recognized nuclear targeting signal of parathyroid hormone-related protein.Biochem Biophys Res Commun. 2001 Mar 30;282(2):629-34. doi: 10.1006/bbrc.2001.4607. Biochem Biophys Res Commun. 2001. PMID: 11401507
-
Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha.J Biol Chem. 1999 Mar 12;274(11):7391-8. doi: 10.1074/jbc.274.11.7391. J Biol Chem. 1999. PMID: 10066803
-
Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules.Mol Endocrinol. 2002 Feb;16(2):390-401. doi: 10.1210/mend.16.2.0775. Mol Endocrinol. 2002. PMID: 11818509
-
Biological action of parathyroid hormone (PTH)-related peptide (PTHrP) mediated either by the PTH/PTHrP receptor or the nucleolar translocation in chondrocytes.Anat Sci Int. 2002 Dec;77(4):225-36. doi: 10.1046/j.0022-7722.2002.00032.x. Anat Sci Int. 2002. PMID: 12557418 Review.
Cited by
-
PTH-rP and PTH-R1 Expression in Placentas from Pregnancies Complicated by Gestational Diabetes: New Insights into the Pathophysiology of Hyperglycemia in Pregnancy.Diagnostics (Basel). 2021 Jul 28;11(8):1356. doi: 10.3390/diagnostics11081356. Diagnostics (Basel). 2021. PMID: 34441291 Free PMC article.
-
Multiple actions of parathyroid hormone-related protein in breast cancer bone metastasis.Br J Pharmacol. 2021 May;178(9):1923-1935. doi: 10.1111/bph.14709. Epub 2019 Jul 2. Br J Pharmacol. 2021. PMID: 31087800 Free PMC article. Review.
-
Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: implications for transformation.Retrovirology. 2008 Jun 9;5:46. doi: 10.1186/1742-4690-5-46. Retrovirology. 2008. PMID: 18541021 Free PMC article.
-
New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases.Chem Rev. 2015 Mar 25;115(6):2453-81. doi: 10.1021/cr5004248. Epub 2015 Jan 9. Chem Rev. 2015. PMID: 25575290 Free PMC article. Review. No abstract available.
-
ORF73 LANA homologs of RRV and MneRV2 contain an extended RGG/RG-rich nuclear and nucleolar localization signal that interacts directly with importin β1 for non-classical nuclear import.Virology. 2017 Nov;511:152-164. doi: 10.1016/j.virol.2017.08.029. Epub 2017 Aug 29. Virology. 2017. PMID: 28850829 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
