Review
doi: 10.1016/s0962-8924(00)01803-1.
Mitochondria as the central control point of apoptosis
Affiliations
- PMID: 10932094
- DOI: 10.1016/s0962-8924(00)01803-1
Item in Clipboard
Review
Mitochondria as the central control point of apoptosis
Trends Cell Biol.
2000 Sep.
Abstract
Mitochondria play a major role in apoptosis triggered by many stimuli. They integrate death signals through Bcl-2 family members and coordinate caspase activation through the release of cytochrome c as a result of the outer mitochondrial membrane becoming permeable. The mechanisms that lead to this permeability are not yet completely understood. Here, we attempt to summarize our current view of the mechanisms that lead to the efflux of many proteins from mitochondria during apoptosis and the role played by Bcl-2 family proteins in the control of this event.
Comment in
-
Solange Desagher and Jean-Claude Martinou: Executioners of Cell Death.Trends Cell Biol. 2016 Aug;26(8):560-562. doi: 10.1016/j.tcb.2016.05.010. Epub 2016 Jun 20. Trends Cell Biol. 2016. PMID: 27339938 No abstract available.
Similar articles
-
Regulation of Bcl-2 proteins and of the permeability of the outer mitochondrial membrane.C R Biol. 2005 Jul;328(7):616-31. doi: 10.1016/j.crvi.2005.05.002. C R Biol. 2005. PMID: 15992745 Review.
-
Apoptosis: bombarding the mitochondria.Essays Biochem. 2003;39:41-51. doi: 10.1042/bse0390041. Essays Biochem. 2003. PMID: 14585073 Review.
-
[Apoptosis: mitochondrial membrane permeabilization and the role played by Bcl-2 family proteins].Postepy Hig Med Dosw (Online). 2004;58:538-47. Postepy Hig Med Dosw (Online). 2004. PMID: 15765016 Review. Polish.
-
[Changes in the outer mitochondrial membranes during apoptosis].J Soc Biol. 2005;199(3):207-10. doi: 10.1051/jbio:2005021. J Soc Biol. 2005. PMID: 16471260 Review. French.
-
Bcl-2 family of proteins: life-or-death switch in mitochondria.Biosci Rep. 2002 Feb;22(1):47-58. doi: 10.1023/a:1016061006256. Biosci Rep. 2002. PMID: 12418550 Review.
Cited by
-
Spiclomazine induces apoptosis associated with the suppression of cell viability, migration and invasion in pancreatic carcinoma cells.PLoS One. 2013 Jun 20;8(6):e66362. doi: 10.1371/journal.pone.0066362. Print 2013. PLoS One. 2013. PMID: 23840452 Free PMC article.
-
Rhein Elicits In Vitro Cytotoxicity in Primary Human Liver HL-7702 Cells by Inducing Apoptosis through Mitochondria-Mediated Pathway.Evid Based Complement Alternat Med. 2015;2015:329831. doi: 10.1155/2015/329831. Epub 2015 Jun 14. Evid Based Complement Alternat Med. 2015. PMID: 26221172 Free PMC article.
-
Alterations in c-Myc phenotypes resulting from dynamin-related protein 1 (Drp1)-mediated mitochondrial fission.Cell Death Dis. 2013 Jun 13;4(6):e670. doi: 10.1038/cddis.2013.201. Cell Death Dis. 2013. PMID: 23764851 Free PMC article.
-
18α-Glycyrrhetinic Acid Induces Apoptosis of HL-60 Human Leukemia Cells through Caspases- and Mitochondria-Dependent Signaling Pathways.Molecules. 2016 Jul 1;21(7):872. doi: 10.3390/molecules21070872. Molecules. 2016. PMID: 27376261 Free PMC article.
-
Catalpol inhibits apoptosis in hydrogen peroxide-induced cardiac myocytes through a mitochondrial-dependent caspase pathway.Biosci Rep. 2016 Jun 30;36(3):e00348. doi: 10.1042/BSR20160132. Print 2016 Jul. Biosci Rep. 2016. PMID: 27166426 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
