Transcriptional silencing in fission yeast
- PMID: 10911361
- DOI: 10.1002/1097-4652(200009)184:3<311::AID-JCP4>3.0.CO;2-D
Transcriptional silencing in fission yeast
Abstract
In eukaryotes, epigenetic events govern diverse processes, ranging from gene expression to other aspects of global chromosome architecture essential for preserving the integrity of the genome. Transcriptional silencing at the mating-type locus, centromeres, and telomeres of the fission yeast is regulated by epigenetic mechanisms. Epigenetic states are inherited in cis during mitosis and, remarkably, even through meiosis. Several trans-acting genes that affect silencing are found to encode either chromatin proteins such as chromodomain proteins Swi6 and Clr4 or the factors that affect chromatin assembly, including histone deacetylase homologs Clr3 and Clr6. A recent study showed that Swi6 is involved in imprinting at the mating-type locus and contributes to the cellular memory responsible for maintenance of the silenced state. The "gene" in this instance thus comprises DNA plus the associated Swi6-containing protein complex.
Copyright 2000 Wiley-Liss, Inc.
Similar articles
-
A novel type of silencing factor, Clr2, is necessary for transcriptional silencing at various chromosomal locations in the fission yeast Schizosaccharomyces pombe.Nucleic Acids Res. 2004 Aug 18;32(15):4421-8. doi: 10.1093/nar/gkh780. Print 2004. Nucleic Acids Res. 2004. PMID: 15317867 Free PMC article.
-
Histone deacetylase homologs regulate epigenetic inheritance of transcriptional silencing and chromosome segregation in fission yeast.Genetics. 1998 Oct;150(2):563-76. doi: 10.1093/genetics/150.2.563. Genetics. 1998. PMID: 9755190 Free PMC article.
-
Role of heterochromatin in suppressing subtelomeric recombination in fission yeast.Yeast. 2008 Aug;25(8):537-48. doi: 10.1002/yea.1603. Yeast. 2008. PMID: 18615848
-
Studies on the mechanism of RNAi-dependent heterochromatin assembly.Cold Spring Harb Symp Quant Biol. 2006;71:461-71. doi: 10.1101/sqb.2006.71.044. Cold Spring Harb Symp Quant Biol. 2006. PMID: 17381328 Review.
-
Homologous chromosome pairing in Schizosaccharomyces pombe.Yeast. 2006 Oct 15;23(13):977-89. doi: 10.1002/yea.1403. Yeast. 2006. PMID: 17072890 Review.
Cited by
-
Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast.Nat Commun. 2015 Jul 24;6:7753. doi: 10.1038/ncomms8753. Nat Commun. 2015. PMID: 26205977 Free PMC article.
-
A new method to efficiently induce a site-specific double-strand break in the fission yeast Schizosaccharomyces pombe.Yeast. 2012 Jul;29(7):275-91. doi: 10.1002/yea.2908. Epub 2012 Jun 6. Yeast. 2012. PMID: 22674789 Free PMC article.
-
The enhancer-blocking activity of the Fab-7 boundary from the Drosophila bithorax complex requires GAGA-factor-binding sites.Genetics. 2004 Nov;168(3):1371-84. doi: 10.1534/genetics.104.029561. Genetics. 2004. PMID: 15579691 Free PMC article.
-
A role for DNA polymerase alpha in epigenetic control of transcriptional silencing in fission yeast.EMBO J. 2001 Jun 1;20(11):2857-66. doi: 10.1093/emboj/20.11.2857. EMBO J. 2001. PMID: 11387218 Free PMC article.
-
Redundant roles for histone H3 N-terminal lysine residues in subtelomeric gene repression in Saccharomyces cerevisiae.Genetics. 2004 Jul;167(3):1123-32. doi: 10.1534/genetics.104.026674. Genetics. 2004. PMID: 15280228 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
