Basal ganglia neurotoxins
- PMID: 10873237
- DOI: 10.1016/s0733-8619(05)70217-6
Basal ganglia neurotoxins
Abstract
The epidemiology, clinical features, pathology, and mechanisms of action of basal ganglia neurotoxins are reviewed. Manganese, cyanide, hydrogen sulfide, methanol, carbon monoxide, 3-nitropropionic acid, MPTP, and annonaceae alkaloids are discussed. The probable mechanism of action for almost all basal ganglia neurotoxins is inhibition of mitochondrial function with destruction of the pallidum and putamen. MPTP produces selective loss of dopaminergic neurons because of selective uptake of a toxic metabolite in dopaminergic neurons. The basis for selective vulnerability of the putamen and pallidum is unknown.
Similar articles
-
Reduced basal ganglia volumes after switching to olanzapine in chronically treated patients with schizophrenia.Am J Psychiatry. 2004 Oct;161(10):1829-36. doi: 10.1176/ajp.161.10.1829. Am J Psychiatry. 2004. PMID: 15465980 Clinical Trial.
-
Carbon monoxide poisoning-induced nigrostriatal dopaminergic dysfunction detected using positron emission tomography (PET).Neurotoxicology. 2010 Aug;31(4):403-7. doi: 10.1016/j.neuro.2010.03.006. Epub 2010 Mar 24. Neurotoxicology. 2010. PMID: 20346372
-
Basal ganglia T2 relaxation times in schizophrenia: a quantitative magnetic resonance imaging study in relation to tardive dyskinesia.Psychiatry Res. 1995 Aug 8;61(2):95-102. doi: 10.1016/0925-4927(95)02591-k. Psychiatry Res. 1995. PMID: 7480392
-
The mammalian striatum and neurotoxic injury.Brain Pathol. 2002 Oct;12(4):482-7. doi: 10.1111/j.1750-3639.2002.tb00466.x. Brain Pathol. 2002. PMID: 12408235 Free PMC article. Review. No abstract available.
-
[Methanol poisoning with bilateral necrosis of the putamen and additional involvement of the globus pallidus].Rofo. 1997 Jul;167(1):99-100. doi: 10.1055/s-2007-1015500. Rofo. 1997. PMID: 9289052 Review. German. No abstract available.
Cited by
-
Uremic Encephalopathy: MR Imaging Findings and Clinical Correlation.AJNR Am J Neuroradiol. 2016 Sep;37(9):1604-9. doi: 10.3174/ajnr.A4776. Epub 2016 Apr 28. AJNR Am J Neuroradiol. 2016. PMID: 27127003 Free PMC article.
-
Chemical warfare agents.J Pharm Bioallied Sci. 2010 Jul;2(3):166-78. doi: 10.4103/0975-7406.68498. J Pharm Bioallied Sci. 2010. PMID: 21829312 Free PMC article.
-
Developmental exposure to manganese increases adult susceptibility to inflammatory activation of glia and neuronal protein nitration.Toxicol Sci. 2009 Dec;112(2):405-15. doi: 10.1093/toxsci/kfp221. Epub 2009 Oct 7. Toxicol Sci. 2009. PMID: 19812365 Free PMC article.
-
Bipallidal haemorrhage after ethylene glycol intoxication.Neuroradiology. 2005 Feb;47(2):105-7. doi: 10.1007/s00234-005-1347-y. Epub 2005 Feb 16. Neuroradiology. 2005. PMID: 15714272
-
Chronic carbon disulfide exposure induces parkinsonian pathology via α-synuclein aggregation and necrosome complex interaction.iScience. 2023 Aug 30;26(10):107787. doi: 10.1016/j.isci.2023.107787. eCollection 2023 Oct 20. iScience. 2023. PMID: 37731606 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources