Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2000 Feb;77(2):105-10.
doi: 10.4314/eamj.v77i2.46410.

Randomised trial of alternative malaria chemoprophylaxis strategies among pregnant women in Kigoma, Tanzania: II. Results from baseline studies

S K Mnyika  1 , T K Kabalimu, G Mbaruku, R Masisila, W Mpanju-Shumbusho
Affiliations
Clinical Trial

Randomised trial of alternative malaria chemoprophylaxis strategies among pregnant women in Kigoma, Tanzania: II. Results from baseline studies

S K Mnyika et al. East Afr Med J. 2000 Feb.

Abstract

Objective: To determine baseline data among pregnant women consenting to participate in a randomised trial of alternative strategies of malaria chemoprophylaxis in Kigoma urban district, western Tanzania.

Design: Cross-sectional study.

Setting: The study was conducted in an urban MCH clinic in Kigoma town in western Tanzania.

Subjects: All consenting pregnant women who fulfilled entry criteria were recruited into the study. BASELINE STUDIES: Baseline data were collected prior to randomisation of women to antimalarial prophylactic regimens. Baseline measurements included examination for blood depleting parasitic infections (stool and urine examinations), haemoglobin levels, haematocrit, sickling test, and blood slide for malaria parasites.

Results: A total of 728 pregnant women consented to participate in the interview and of these 705 participated in baseline studies constituting a participation rate of 96.8%. The age of participating women ranged from 14 to 45 years with a mean age of 23.7 years (standard deviation [SD] = 5.4) while the mean number of pregnancies ranged from 1 to 13 with a mean of 3.2 (SD = 2.2). The prevalence of malaria parasitaemia among the pregnant women examined was 9.4% (N = 705) while the prevalence of anaemia (defined as Hb < 8.5 gdl-1) was 12.4% (N = 579). No significant difference was observed in prevalence proportions of malaria parasitaemia in relation to age, parity, marital status and use of mosquito bednets. However the prevalence of anaemia among women in the age group 31-45 years was significantly lower than that observed among women in the age group 14-20 years (2.9% versus 18.9%; crude odds ratio [OR] = 0.13; 95% confidence interval [CI], 0.02-0.55). Sickle cell disease (HbAS) was found in 2.3% (N = 564) of the pregnant women examined.

Conclusion: It is concluded that the prevalence of malaria parasitaemia and anaemia was very high in this population suggesting the need for interventions directed at controlling these major causes of maternal morbidity and mortality in Tanzania.

PIP: This cross-sectional study conducted in Kigoma urban district, western Tanzania, determined the baseline data among pregnant women consenting to participate in a randomized trial of alternative malaria chemoprophylaxis strategies. Baseline data were obtained prior to randomization of women to antimalarial prophylactic regimens (intermittent or continuous chloroquine and proguanil). Baseline measurements included examination for blood depleting parasitic infections (stool and urine examinations), hemoglobin levels, hematocrit, sickling test, and blood slide for malaria parasites. A total of 728 pregnant women consented to participate, and of these, 705 participated in baseline studies constituting a participation rate of 96.8%. The age range was 14-45 years, while the number of pregnancies ranged from 1 to 13. The prevalence of malaria parasitemia among the subjects was 9.4% (N = 705), while the prevalence of anemia was 12.4% (N = 579). There was no significant difference in prevalence proportions of malaria parasitemia in relation to age, parity, marital status and use of mosquito bednets. However, the prevalence of anemia among women aged 31-14 years was significantly lower than among women in the age group 14-20 years (2.9% vs. 18.9%; crude odds ratio = 0.13; 95% confidence interval, 0.02-0.55). Sickle cell disease (HbAS) was found in 2.3% (N = 564) of the pregnant women examined. The prevalence of malaria parasitemia and anemia was very high in this population, suggesting the need for effective disease control interventions.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

Publication types

MeSH terms

LinkOut - more resources