Induction of apoptosis by cancer chemotherapy
- PMID: 10739650
- DOI: 10.1006/excr.2000.4838
Induction of apoptosis by cancer chemotherapy
Abstract
Studies performed over the past five years have demonstrated that there are two major cell-intrinsic pathways for inducing apoptosis, one that begins with ligation of cell surface death receptors and another that involves mitochondrial release of cytochrome c. Several reports have suggested that anticancer drugs kill susceptible cells by inducing expression of death receptor ligands, especially Fas ligand (FasL). Other reports have indicated that chemotherapeutic agents trigger apoptosis by inducing release of cytochrome c from mitochondria. In this review, we describe the two prototypic death pathways, indicate experimental approaches for distinguishing whether chemotherapeutic agents trigger one pathway or the other, summarize current understanding of the role of the two pathways in chemotherapy-induced apoptosis, and discuss the implications of these studies for mechanisms of resistance to chemotherapeutic agents.
Copyright 2000 Academic Press.
Similar articles
-
Shared pathways: death receptors and cytotoxic drugs in cancer therapy.Pathol Oncol Res. 2001;7(2):95-106. doi: 10.1007/BF03032574. Pathol Oncol Res. 2001. PMID: 11458271 Review.
-
Modulation of death receptor pathways in oncology.Drugs Today (Barc). 2003;39 Suppl C:95-109. Drugs Today (Barc). 2003. PMID: 14988748 Review.
-
Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway.Oncogene. 2003 Apr 3;22(13):2034-44. doi: 10.1038/sj.onc.1206290. Oncogene. 2003. PMID: 12673208
-
Role of the Fas/Fas ligand death receptor pathway in ginseng saponin metabolite-induced apoptosis in HepG2 cells.Arch Pharm Res. 2004 Apr;27(4):402-6. doi: 10.1007/BF02980081. Arch Pharm Res. 2004. PMID: 15180305
-
How melanoma cells evade trail-induced apoptosis.Nat Rev Cancer. 2001 Nov;1(2):142-50. doi: 10.1038/35101078. Nat Rev Cancer. 2001. PMID: 11905805 Review.
Cited by
-
2-Aminoethyl Dihydrogen Phosphate (2-AEH2P) Associated with Cell Metabolism-Modulating Drugs Presents a Synergistic and Pro-Apoptotic Effect in an In Vitro Model of the Ascitic Ehrlich Tumor.Biomedicines. 2024 Jan 4;12(1):109. doi: 10.3390/biomedicines12010109. Biomedicines. 2024. PMID: 38255214 Free PMC article.
-
Suppression of Bcl3 Disrupts Viability of Breast Cancer Cells through Both p53-Dependent and p53-Independent Mechanisms via Loss of NF-κB Signalling.Biomedicines. 2024 Jan 10;12(1):143. doi: 10.3390/biomedicines12010143. Biomedicines. 2024. PMID: 38255248 Free PMC article.
-
Centaurea bruguierana inhibits cell proliferation, causes cell cycle arrest, and induces apoptosis in human MCF-7 breast carcinoma cells.Mol Biol Rep. 2020 Aug;47(8):6043-6051. doi: 10.1007/s11033-020-05679-x. Epub 2020 Jul 22. Mol Biol Rep. 2020. PMID: 32700127
-
Cabazitaxel-induced autophagy via the PI3K/Akt/mTOR pathway contributes to A549 cell death.Mol Med Rep. 2016 Oct;14(4):3013-20. doi: 10.3892/mmr.2016.5648. Epub 2016 Aug 19. Mol Med Rep. 2016. PMID: 27572899 Free PMC article.
-
CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak.J Biol Chem. 2013 Aug 9;288(32):22899-914. doi: 10.1074/jbc.M113.449926. Epub 2013 Jun 24. J Biol Chem. 2013. PMID: 23798675 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
