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. 2000 Apr;78(4):2180-5.
doi: 10.1016/S0006-3495(00)76765-8.

F-actin retains a memory of angular order

A Orlova  1 , E H Egelman
Affiliations

F-actin retains a memory of angular order

A Orlova et al. Biophys J. 2000 Apr.

Abstract

Modifications can be made to F-actin that do not interfere with the binding of myosin but inhibit force generation, suggesting that actin's internal dynamics are important for muscle contraction. Observations from electron microscopy and x-ray diffraction have shown that subunits in F-actin have a relatively fixed axial rise but a variable twist. One possible explanation for this is that the actin subunits randomly exist in different discrete states of "twist, " with a significant energy barrier separating these states. This would result in very slow torsional transitions. Paracrystals impose increased order on F-actin filaments by reducing the variability in twist. By looking at filaments that have recently been dissociated from paracrystals, we find that F-actin retains a "memory" of its previous environment that persists for many seconds. This would be consistent with slow torsional transitions between discrete states of twist.

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References

    1. J Mol Biol. 1999 Nov 19;294(1):139-49 - PubMed
    1. Biophys J. 1999 Apr;76(4):1770-83 - PubMed
    1. Cold Spring Harb Symp Quant Biol. 1982;46 Pt 2:525-40 - PubMed
    1. J Mol Biol. 1983 Jun 5;166(4):605-29 - PubMed
    1. J Biochem. 1983 Jun;93(6):1705-7 - PubMed

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