Human cytomegalovirus infection of immature dendritic cells and macrophages
- PMID: 10702719
- DOI: 10.1159/000053973
Human cytomegalovirus infection of immature dendritic cells and macrophages
Abstract
A central aspect of human cytomegalovirus (HCMV) pathogenesis is the interaction of the virus with different antigen-presenting cell (APC) types of the host. In principle, a number of various cell types have the potential of antigen presentation when MHC II expression is induced by appropriate stimuli. The most potent antigen presenters are monocytes/macrophages and dendritic cells (DCs), therefore called professional APCs. Interestingly, these cells seem to be targets of productive HCMV infection. The susceptibility of the monocyte/macrophage system has been analyzed intensively during the past decade. Investigation of the role of DCs during HCMV infection, however, has begun only recently.
Copyright 2000 S. Karger AG, Basel.
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