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. 2000 Feb;26(1):44-6.
doi: 10.1136/jme.26.1.44.

Live attenuated vaccine trials in medically informed volunteers: a special case?

A J Pinching  1
Affiliations

Live attenuated vaccine trials in medically informed volunteers: a special case?

A J Pinching. J Med Ethics. 2000 Feb.

Abstract

A group of activist clinicians have offered to volunteer for clinical trials of live attenuated HIV vaccines. This has provided an important conceptual challenge to medical ethics, and to work on the development of HIV vaccines. In exploring these issues, this article highlights how the HIV field has altered the content as well as the tone of ethical discourse. The balance of expertise and authority between research subjects and triallists is profoundly changed, raising questions about the limits of voluntarism and differing perspectives on risk-benefit analysis. Care is needed to ensure that the novelty of the situation does not confuse the central ethical and scientific issues.

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