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. 1976 Nov;73(11):3812-5.
doi: 10.1073/pnas.73.11.3812.

Nuclear magnetic resonance description of molecular motion and phase separations of cholesterol in lecithin dispersions

S J Opella, J P Yesinowski, J S Waugh

Nuclear magnetic resonance description of molecular motion and phase separations of cholesterol in lecithin dispersions

S J Opella et al. Proc Natl Acad Sci U S A. 1976 Nov.

Abstract

Proton-enhanced 13C nuclear magnetic resonance is used to obtain signals from labeled cholesterols in lecithin dispersions. The [26-(13)C]cholesterol resonance indicates that the aliphatic tail of the molecule undergoes reorientation fast enough to average completely the chemical shift anisotropy. In contrast, [4-(13)C]cholesterol signals are characteristic of limited anisotropic reorientation. The resonances from the 4 position are sensitive to the temperature-concentration phase diagram. A phase boundary is observed at about 20 mole percent cholesterol.

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