Review
doi: 10.1038/sj.onc.1203244.
The retinoblastoma gene family in differentiation and development
Affiliations
- PMID: 10630640
- DOI: 10.1038/sj.onc.1203244
Item in Clipboard
Review
The retinoblastoma gene family in differentiation and development
Oncogene.
.
Abstract
The retinoblastoma (Rb) tumor suppressor gene and its close relatives p107 and p130 are best known for their function in the control of cell cycle progression. In recent years, however, a new role for these proteins has been emerging as they have been linked with regulation of terminal differentiation of many tissues and cell types. In fact, Rb and its family members have been shown to be involved in multiple stages of the differentiation process including irreversible exit from the cell cycle, protection from apoptosis, induction of cell type specific gene expression and maintenance of the post-mitotic state. They also play a critical role in assuring the orderly progression through all these stages of differentiation.
Similar articles
-
The retinoblastoma gene family and its role in proliferation, differentiation and development.Histol Histopathol. 1996 Oct;11(4):1029-34. Histol Histopathol. 1996. PMID: 8930645 Review.
-
Cell cycle control and beyond: emerging roles for the retinoblastoma gene family.Oncogene. 2006 Aug 28;25(38):5201-9. doi: 10.1038/sj.onc.1209652. Oncogene. 2006. PMID: 16936738 Review.
-
The retinoblastoma gene: its role in cell cycle and cancer.In Vivo. 1996 Mar-Apr;10(2):223-7. In Vivo. 1996. PMID: 8744804 Review.
-
RB, the conductor that orchestrates life, death and differentiation.Oncogene. 2006 Aug 28;25(38):5210-9. doi: 10.1038/sj.onc.1209612. Oncogene. 2006. PMID: 16936739 Review.
-
Genes in the RB pathway and their knockout in mice.Semin Cancer Biol. 1996 Oct;7(5):279-89. doi: 10.1006/scbi.1996.0036. Semin Cancer Biol. 1996. PMID: 9110405 Review.
Cited by
-
Regulation of Yorkie activity in Drosophila imaginal discs by the Hedgehog receptor gene patched.Mech Dev. 2012 Sep-Dec;129(9-12):339-49. doi: 10.1016/j.mod.2012.05.007. Epub 2012 Jun 15. Mech Dev. 2012. PMID: 22705500 Free PMC article.
-
T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis.Microbiol Mol Biol Rev. 2002 Jun;66(2):179-202. doi: 10.1128/MMBR.66.2.179-202.2002. Microbiol Mol Biol Rev. 2002. PMID: 12040123 Free PMC article. Review.
-
Cell-nonautonomous function of the retinoblastoma tumour suppressor protein: new interpretations of old phenotypes.EMBO Rep. 2002 Feb;3(2):130-5. doi: 10.1093/embo-reports/kvf033. EMBO Rep. 2002. PMID: 11839697 Free PMC article. Review.
-
ARF mutation accelerates pituitary tumor development in Rb+/- mice.Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16865-70. doi: 10.1073/pnas.262499599. Epub 2002 Dec 16. Proc Natl Acad Sci U S A. 2002. PMID: 12486224 Free PMC article.
-
The role of HPV E6 and E7 oncoproteins in HPV-associated cervical carcinogenesis.Cancer Res Treat. 2005 Dec;37(6):319-24. doi: 10.4143/crt.2005.37.6.319. Epub 2005 Dec 31. Cancer Res Treat. 2005. PMID: 19956366 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
