Deubiquitinating enzymes: their diversity and emerging roles
- PMID: 10603300
- DOI: 10.1006/bbrc.1999.1880
Deubiquitinating enzymes: their diversity and emerging roles
Abstract
A growing number of important regulatory proteins within cells are modified by conjugation of ubiquitin, a well-conserved 76-amino-acid polypeptide. The ubiquitinated proteins are targeted to proteasome for degradation or alternative metabolic fates, such as triggering of plasma membrane endocytosis and trafficking to vacuoles or lysosomes. Deubiquitination, reversal of this modification, is being recognized as an important regulatory step. Deubiquitinating enzymes are cysteine proteases that specifically cleave off ubiquitin from ubiquitin-conjugated protein substrates as well as from its precursor proteins. Genome sequencing projects have identified more than 90 deubiquitinating enzymes, making them the largest family of enzymes in the ubiquitin system. This review will concentrate on recent important findings as well as new insights into the diversity and emerging roles of deubiquitinating enzymes in the ubiquitin-dependent pathway.
Copyright 1999 Academic Press.
Similar articles
-
Deubiquitinating enzymes: a new class of biological regulators.Crit Rev Biochem Mol Biol. 1998;33(5):337-52. doi: 10.1080/10409239891204251. Crit Rev Biochem Mol Biol. 1998. PMID: 9827704 Review.
-
Deubiquitinating enzymes as cellular regulators.J Biochem. 2003 Jul;134(1):9-18. doi: 10.1093/jb/mvg107. J Biochem. 2003. PMID: 12944365 Review.
-
A cryptic protease couples deubiquitination and degradation by the proteasome.Nature. 2002 Sep 26;419(6905):403-7. doi: 10.1038/nature01071. Epub 2002 Sep 1. Nature. 2002. PMID: 12353037
-
Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation.Nat Cell Biol. 2001 Aug;3(8):740-4. doi: 10.1038/35087056. Nat Cell Biol. 2001. PMID: 11483959
-
Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.Am J Hematol. 2002 Dec;71(4):340-5. doi: 10.1002/ajh.10243. Am J Hematol. 2002. PMID: 12447969 Review.
Cited by
-
Saccharomyces cerevisiae SMT4 encodes an evolutionarily conserved protease with a role in chromosome condensation regulation.Genetics. 2001 May;158(1):95-107. doi: 10.1093/genetics/158.1.95. Genetics. 2001. PMID: 11333221 Free PMC article.
-
Replaceable neurons and neurodegenerative disease share depressed UCHL1 levels.Proc Natl Acad Sci U S A. 2005 May 31;102(22):8036-41. doi: 10.1073/pnas.0503239102. Epub 2005 May 23. Proc Natl Acad Sci U S A. 2005. PMID: 15911766 Free PMC article.
-
High expression of UCH37 is significantly associated with poor prognosis in human epithelial ovarian cancer.Tumour Biol. 2014 Nov;35(11):11427-33. doi: 10.1007/s13277-014-2446-3. Epub 2014 Aug 15. Tumour Biol. 2014. PMID: 25123264
-
Antagonistic regulation of myogenesis by two deubiquitinating enzymes, UBP45 and UBP69.Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9733-8. doi: 10.1073/pnas.152011799. Epub 2002 Jul 9. Proc Natl Acad Sci U S A. 2002. PMID: 12107281 Free PMC article.
-
Babela massiliensis, a representative of a widespread bacterial phylum with unusual adaptations to parasitism in amoebae.Biol Direct. 2015 Mar 31;10:13. doi: 10.1186/s13062-015-0043-z. Biol Direct. 2015. PMID: 25884386 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
