Acoustic and current-pulse responses of identified neurons in the dorsal cochlear nucleus of unanesthetized, decerebrate gerbils
- PMID: 10601474
- DOI: 10.1152/jn.1999.82.6.3434
Acoustic and current-pulse responses of identified neurons in the dorsal cochlear nucleus of unanesthetized, decerebrate gerbils
Abstract
In an effort to establish relationships between cell physiology and morphology in the dorsal cochlear nucleus (DCN), intracellular single-unit recording and marking experiments were conducted on decerebrate gerbils using horseradish peroxidase (HRP)- or neurobiotin-filled micropipettes. Intracellular responses to acoustic (tone and broadband noise bursts) and electric current-pulse stimuli were recorded and associated with cell morphology. Units were classified according to the response map scheme (type I to type V). Results from 19 identified neurons, including 13 fusiform cells, 2 giant cells, and 4 cartwheel cells, reveal correlations between cell morphology of these neurons and their acoustic responses. Most fusiform cells (8/13) are associated with type III unit response properties. A subset of fusiform cells was type I/III units (2), type III-i units (2), and a type IV-T unit. The giant cells were associated with type IV-i unit response properties. Cartwheel cells all had weak acoustic responses that were difficult to classify. Some measures of membrane properties also were correlated with cell morphology but to a lesser degree. Giant cells and all but one fusiform cell fired only simple action potentials (APs), whereas all cartwheel cells discharged complex APs. Giant and fusiform cells all had monotonic rate versus current level curves, whereas cartwheel cells had nonmonotonic curves. This implies that inhibitory acoustic responses, resulting in nonmonotonic rate versus sound level curves, are due to local inhibitory interactions rather than strictly to membrane properties. A complex-spiking fusiform cell with type III unit properties suggests that cartwheel cells are not the only complex-spiking cells in DCN. The diverse response properties of the DCN's fusiform cells suggests that they are very sensitive to the specific complement of excitatory and inhibitory inputs they receive.
Similar articles
-
Intracellular response properties of units in the dorsal cochlear nucleus of unanesthetized decerebrate gerbil.J Neurophysiol. 1997 May;77(5):2549-72. doi: 10.1152/jn.1997.77.5.2549. J Neurophysiol. 1997. PMID: 9163376
-
Spontaneous and sound-evoked discharge characteristics of complex-spiking neurons in the dorsal cochlear nucleus of the unanesthetized decerebrate cat.J Neurophysiol. 1995 Feb;73(2):550-61. doi: 10.1152/jn.1995.73.2.550. J Neurophysiol. 1995. PMID: 7760117
-
Response properties of units in the dorsal cochlear nucleus of unanesthetized decerebrate gerbil.J Neurophysiol. 1996 Apr;75(4):1411-31. doi: 10.1152/jn.1996.75.4.1411. J Neurophysiol. 1996. PMID: 8727387
-
Somatosensory effects on neurons in dorsal cochlear nucleus.J Neurophysiol. 1995 Feb;73(2):743-65. doi: 10.1152/jn.1995.73.2.743. J Neurophysiol. 1995. PMID: 7760132
-
Single neuron recordings in dorsal cochlear nucleus (DCN) of awake gerbil.Hear Res. 2009 Sep;255(1-2):44-57. doi: 10.1016/j.heares.2009.05.004. Epub 2009 May 18. Hear Res. 2009. PMID: 19450672
Cited by
-
Voltage-gated potassium channel (Kv) subunits expressed in the rat cochlear nucleus.J Histochem Cytochem. 2008 May;56(5):443-65. doi: 10.1369/jhc.2008.950303. Epub 2008 Feb 5. J Histochem Cytochem. 2008. PMID: 18256021 Free PMC article.
-
Listening in complex acoustic scenes.Curr Opin Physiol. 2020 Dec;18:63-72. doi: 10.1016/j.cophys.2020.09.001. Epub 2020 Sep 8. Curr Opin Physiol. 2020. PMID: 33479600 Free PMC article.
-
Hazard functions and expected spike density functions for neuron spike activity in the cochlear nucleus of the cat.Neurosci Behav Physiol. 2005 Jan;35(1):59-70. doi: 10.1023/b:neab.0000049652.93984.da. Neurosci Behav Physiol. 2005. PMID: 15739789
-
Single-neuron recordings from unanesthetized mouse dorsal cochlear nucleus.J Neurophysiol. 2012 Feb;107(3):824-35. doi: 10.1152/jn.00427.2011. Epub 2011 Nov 9. J Neurophysiol. 2012. PMID: 22072506 Free PMC article.
-
Control of firing patterns by two transient potassium currents: leading spike, latency, bistability.J Comput Neurosci. 2011 Aug;31(1):117-36. doi: 10.1007/s10827-010-0297-5. Epub 2010 Dec 22. J Comput Neurosci. 2011. PMID: 21181249 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous