doi: 10.1093/jac/44.5.705.
Cytopathic effect inhibition assay for determining the in-vitro susceptibility of herpes simplex virus to antiviral agents
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- PMID: 10552991
- DOI: 10.1093/jac/44.5.705
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Cytopathic effect inhibition assay for determining the in-vitro susceptibility of herpes simplex virus to antiviral agents
J Antimicrob Chemother.
1999 Nov.
Abstract
We compare a rapid dilution method for the determination of antiviral susceptibility of herpes simplex virus (HSV) with the plaque reduction assay. A total of 84 HSV clinical isolates were studied by both methods to detect in-vitro resistance to acyclovir and foscarnet. The rapid method showed for the detection of HSV isolates resistant to acyclovir and foscarnet, a sensitivity of 96. 8% and 100% and specificity of 100% and 100%, respectively. This method provides an easy and accurate screening procedure for the susceptibility testing of HSV to antiviral agents.
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